Clinical trial · Observational
Building Research With Artificial Intelligence in Neuro-Ophthalmology
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
The research team, recognized as a world leader in Artificial Intelligence for neuro-ophthalmology, has shown that it is possible to diagnose certain neuro-ophthalmologic or neurologic disorders from a single retinal fundus image (Milea et al, New England Journal of Medicine, 2020). However, clinical practice requires identifying a broader spectrum of diseases (inflammatory, ischemic, hereditary, neurodegenerative) within the same analysis. The main objective is to develop, through a new algorithm capable of classifying multiple disorders from a smaller set of conventional retinal images. This project meets a significant public health need: the global shortage of neuro-ophthalmologists. It aims to provide healthcare professionals with a rapid triage tool to detect serious and treatable conditions, enabling timely intervention. The study will include patients with clearly defined neuro-ophthalmologic or neurologic conditions, confirmed diagnoses, and retinal imaging. Clinical, paraclinical, and imaging data collected during standard care will be used, with strict anonymization according to legal and institutional requirements. Specific Objectives : 1. Evaluate the performance of a diagnostic classification algorithm trained on retinal images. 2. Assess the ability to detect multiple pathologies from a single retinal image. 3. Support the development of advanced computer vision tools for medical diagnostics.
Conditions
Conditions (11)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Artificial Intelligence (AI) | — | UNRESOLVED | — |
| Brain Tumors | Brain Neoplasm | ALIAS | 0.90 |
| Deep Learning | — | UNRESOLVED | — |
| Machine Learning | — | UNRESOLVED | — |
| Optic Atrophy | — | UNRESOLVED | — |
| Optic Nerve Diseases | — | UNRESOLVED | — |
| Optic Neuritis | — | UNRESOLVED | — |
| Optic Neuropathy | — | UNRESOLVED | — |
| Optic Neuropathy, Ischemic | — | UNRESOLVED | — |
Interventions
Interventions (1)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| Deep learning algorithm applied on retrospectively collected color fundus photographs | Other | — | UNRESOLVED |
Design
Arms and outcomes
Arms (0)
[]Primary outcomes (1)
- measure
- Diagnostic performance of the Artificial Intelligence algorithm in detecting multiple neuro-ophthalmologic and neurologic conditions from retinal imaging.
- timeFrame
- baseline
- description
- Evaluation of the algorithm's sensitivity, specificity, and area under the receiver operating caracteristics curve for classifying multiple neuro-ophthalmologic and neurologic pathologies using retinal fundus photography and Optical Coherence Tomography images, compared with expert-established reference diagnoses.
Eligibility
Eligibility (as posted)
- Sex
- All
Show eligibility criteria text
Inclusion Criteria: * Patients with well-defined neuro-ophthalmologic or neurologic conditions, including different forms of optic neuropathies and various neurodegenerative diseases. * Patients with a robust reference diagnosis confirmed by clinical experts. * Patients with available retinal fundus images collected during routine care. Exclusion Criteria: * Patients without a confirmed diagnosis or unclear clinical classification. * Patients without retinal fundus images or with images that are completely unreadable. * Patients whose data cannot be anonymized according to legal and institutional protocols.
References
Publications (1)
- DERIVEDGungor A, Sarbout I, Gilbert AL, Hamann S, Lebranchu P, Hobeanu C, Gohier P, Vignal-Clermont C, Dumitrascu OM, Cohen SY, Lagreze WA, Feltgen N, van der Heide F, Lamirel C, Jonas JB, Obadia M, Racoceanu D, Milea D. Artificial Intelligence-Based Detection of Central Retinal Artery Occlusion Within 4.5 Hours on Standard Fundus Photographs. J Am Heart Assoc. 2025 Jul;14(13):e041441. doi: 10.1161/JAHA.124.041441. Epub 2025 Jun 27. PMID 40576025