Clinical trial · Interventional
Blood and Tissue Extraction for Immunological Examinations During Neoadjuvant Therapy of Soft Tissue Sarcomas
NCT06385288CI-TRIAL-00083405recruitingN/AClinicalTrials.gov clinicaltrialsProvenance
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
"Blood and Tissue Extraction for Immunological Examinations During Neoadjuvant Therapy of Soft Tissue Sarcoma" is a prospective study with additional translational research using preoperative and postoperative tissue, blood sampling and advanced imaging.
Conditions
Conditions (1)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Soft Tissue Sarcoma Adult | Soft Tissue Sarcoma | ONTOLOGY_EXACT | 0.85 |
Interventions
Interventions (2)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| Blood and tissue collection for immunological studies, advanced imaging. | Other | — | UNRESOLVED |
| neoadjuvant Therapy | Other | — | UNRESOLVED |
Design
Arms and outcomes
Arms (1)
- type
- OTHER
- label
- Single-arm trial
- description
- Blood and tissue collection for immunological studies under neoadjuvant Therapy of soft tissue sarcomas. Prospective data collection and translational accompanying research on standard therapy. Use of tissue, blood samples and advanced imaging.
- interventionNames
- Other: Blood and tissue collection for immunological studies, advanced imaging.
- Other: neoadjuvant Therapy
Primary outcomes (5)
- measure
- Description of the cellular immune status via flow-cytometrie from collected blood samples
- timeFrame
- 5 years of recruitment, 5 years follow-up
- description
- Blood samples are taken on the days of simulation-CT, first and third week of the radiation therapy, as well as before surgery.
- measure
- Description of the cellular immune status on tissue samples ussing komplex immunohistochemie
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 18 Years
Show eligibility criteria text
Inclusion Criteria: * Planned histological confirmation for especially high-risk soft tissue sarcoma via open Sampling * Indication for neoadjuvant multimodal therapy (radiation and locoregional Hyperthermia, optionally with simultaneous chemotherapy) * Planned resection of a department of the CWS * Age \> 18 years * Ability to consent * Additionally for imaging study: Treatment on the combined MR hyperthermia device Exclusion Criteria: * Age \< 18 years * Poor understanding (language etc.) * Lack of reconnaissance ability
References
Publications (0)
Data not yet available
No reference posted for this study.