Clinical trial · Observational
Raman Spectroscopy and Skin Cancer
Pilot Study of Raman Spectroscopic Imaging for Skin Cancer
NCT06384924CI-TRIAL-00110796recruitingClinicalTrials.gov clinicaltrialsProvenance
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
The goal of this observational study is to find out if Raman Spectroscopy, a type of imaging, can be used to determine the size of skin cancer tumors. The main question it aims to answer is: -Can Raman Spectroscopy help figure out how far a tumor spreads? This study will take measurements using laser light from an experimental, handheld probe by lightly touching the skin.
Conditions
Conditions (3)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Basal Cell Carcinoma | Basal Cell Carcinoma | ONTOLOGY_EXACT | 0.90 |
| Skin Cancer | Malignant Skin Neoplasm | ALIAS | 0.90 |
| Squamous Cell Carcinoma | Squamous Cell Carcinoma | ONTOLOGY_EXACT | 0.98 |
Interventions
Interventions (2)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| Raman Spectroscopy handheld probe (EmVision, FL, USA) | Device | — | UNRESOLVED |
| Raman Spectroscopy laser source (Hubner Photonics Inc, CA, USA) | Device | — | UNRESOLVED |
Design
Arms and outcomes
Arms (1)
- label
- Raman Spectroscopy
- interventionNames
- Device: Raman Spectroscopy handheld probe (EmVision, FL, USA)
- Device: Raman Spectroscopy laser source (Hubner Photonics Inc, CA, USA)
Primary outcomes (1)
- measure
- Feasibility of Raman Spectroscopy to observe differences in Raman spectra between visible lesion, skin surrounding lesion and contralateral normal skin.
- timeFrame
- 1 year
- description
- Collect the Raman spectroscopy data starting from the center of visible lesion moving outward and also contralateral normal skin. Observe the different spectra peak wavelengths and intensities, which correspond to different chemical composition of the tissue. The Raman Spectra has units of wavelength Raman shift (1/centimeter) on the horizontal axis and arbitrary units of intensity on the vertical axis.
Secondary outcomes (2)
- measure
- Compare the size of clinically defined margin and Raman-defined margin
- timeFrame
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 18 Years
Show eligibility criteria text
Inclusion Criteria: * Histologically confirmed skin cancer (either basal cell carcinoma or squamous cell carcinoma) * Participants must plan to receive brachytherapy treatment for the skin cancer at the study site. * Ability to provide consent to the study. Exclusion Criteria: * Patient belongs to a vulnerable population (Minors (under 18 years old), Adults unable to consent, prisoners). * Lesions on the eyelid or in close proximity to the eye * Pregnant women, or women of childbearing age who refuse pregnancy testing. * Patient has pacemaker.
References
Publications (0)
Data not yet available
No reference posted for this study.