Clinical trial · Interventional
Effects of Topical Sesame Oil in the Prevention of Peripheral Venous Catheter Phlebitis: Clinical Trial.
Effects of Topical Sesame Oil in the Prevention of Chemotherapy-associated Peripheral Venous Catheter Phlebitis: Clinical Trial.
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
Cancer is a disease that, despite having a higher cure rate, is currently on the rise, with an increase in the number of diagnoses. For the treatment of these patients a venous access is required, which in the first treatments is of peripheral insertion. These peripheral venous catheter in combination with the highly aggressive treatments for the veins are the cause of the appearance of chemical phlebitis. Phlebitis is an inflammation caused by a combination of factors, whether chemical, perfusion of irritating medication; mechanical, due to the puncture site, type and fixation of the catheter and infectious, caused by the colonization of pathogenic agents whose origin is the skin and that migrate inward. Phlebitis involves an injury to the wall of the vein, and consequently, the patient will also be at risk of thrombus formation, which in turn leads to thrombophlebitis, deep vein thrombosis or pulmonary embolism. The existence of phlebitis involves intense and constant pain, with increased sensitivity and a sensation of heat and swelling. With the use of topical sesame oil, and thanks to its anti-inflammatory properties, the investigators intend to study whether it is effective in preventing the appearance of phlebitis.
Conditions
Conditions (1)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Phlebitis | — | UNRESOLVED | — |
Interventions
Interventions (2)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| Saline solution | Other | — | UNRESOLVED |
| Sesame oil | Other | — | UNRESOLVED |
Design
Arms and outcomes
Arms (2)
- type
- EXPERIMENTAL
- label
- Intervention
- description
- This arm will be administered 2 drops of sesame oil daily along the channeled vein, about 3 centimeters from the insertion point.
- interventionNames
- Other: Sesame oil
- type
- PLACEBO_COMPARATOR
- label
- Control
- description
- This arm will be administered 2 drops of physiological saline daily along the channeled vein, about 3 centimeters from the insertion point.
- interventionNames
- Other: Saline solution
Primary outcomes (1)
- measure
- Number of phlebitis in oncology patients with peripheral catheter to whom sesame oil is applied topically
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 18 Years
Show eligibility criteria text
Inclusion Criteria: * Be over 18 years of age. * To be conscious and have a cognitive state that allows him/her to give consent to participate in the study. * Be diagnosed with a neoplasm that requires chemotherapy treatment. * To be a carrier of a CVP in the upper extremity as vascular access for chemotherapy administration. Exclusion Criteria: * Being allergic to sesame oil. * Be allergic to nuts. * Not being able to speak, read and write in Spanish. * Last days or palliative situation.
References
Publications (9)
- BACKGROUNDUrbanetto Jde S, Peixoto CG, May TA. Incidence of phlebitis associated with the use of peripheral IV catheter and following catheter removal. Rev Lat Am Enfermagem. 2016 Aug 8;24:e2746. doi: 10.1590/1518-8345.0604.2746. PMID 27508916
- BACKGROUNDWu XF, Yu YJ, Ying LM, Tan WF, Zhan XY, Wang LC. Hot Compress with Chinese Herbal Salt Packets Reducing PICC Catheter Complications: A Randomized Controlled Trial. Chin J Integr Med. 2018 Nov;24(11):809-814. doi: 10.1007/s11655-018-2913-y. Epub 2018 Jun 27. PMID 29946873
- BACKGROUNDSaini V, Samra T, Ahuja N, Sethi S. A prospective randomized study to evaluate safety and efficacy of heparin topical solution (1000 IU/ml) compared to heparin topical gel (200 IU/g) in prevention of infusion-associated phlebitis. Indian J Pharmacol. 2018 Nov-Dec;50(6):344-349. doi: 10.4103/ijp.IJP_201_17. PMID 30783328
- BACKGROUNDBehnamfar N, Parsa Yekta Z, Mojab F, Kazem Naeini SM. The effect of nigella sativa oil on the prevention of phlebitis induced by chemotherapy: a clinical trial. Biomedicine (Taipei). 2019 Sep;9(3):20. doi: 10.1051/bmdcn/2019090320. Epub 2019 Aug 27. PMID 31453801
- BACKGROUNDBagheri-Nesami M, Shorofi SA, Hashemi-Karoie SZ, Khalilian A. The effects of sesame oil on the prevention of amiodarone-induced phlebitis. Iran J Nurs Midwifery Res. 2015 May-Jun;20(3):365-70. PMID 26120338
- BACKGROUNDBigdeli Shamloo MB, Nasiri M, Maneiy M, Dorchin M, Mojab F, Bahrami H, Naseri MS, Kiarsi M. Effects of topical sesame (Sesamum indicum) oil on the pain severity of chemotherapy-induced phlebitis in patients with colorectal cancer: A randomized controlled trial. Complement Ther Clin Pract. 2019 May;35:78-85. doi: 10.1016/j.ctcp.2019.01.016. Epub 2019 Feb 2. PMID 31003690
- BACKGROUNDGoulart CB, Custodio CS, Vasques CI, Ferreira EB, Diniz Dos Reis PE. Effectiveness of topical interventions to prevent or treat intravenous therapy-related phlebitis: A systematic review. J Clin Nurs. 2020 Jul;29(13-14):2138-2149. doi: 10.1111/jocn.15266. Epub 2020 May 20.