Clinical trial · Observational
Prediction of Therapeutic Response to Neoadjuvant Chemotherapy in Muscle Invasive Bladder Cancer Patients Using Spatial Transcriptomics
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
Although neoadjuvant chemotherapy in muscle-invasive bladder cancer has significantly improved oncological outcomes, approximately 50% of patients do not respond to neoadjuvant chemotherapy, which has adverse effects on patients by causing treatment toxicity and surgical delays. Therefore, treatment tailored specifically to the individual patient based on the genetic and/or molecular profile of the patient is urgently needed. Among patients scheduled for neoadjuvant chemotherapy, the investigators should differentiate between patients who will be highly effective with neoadjuvant chemotherapy and those who will not, and preferentially select other treatments including radical cystectomy in the patients with high probability of failure to neoadjuvant chemotherapy. However, there is no standard which patients would benefit from neoadjuvant chemotherapy. This study plans to predict treatment response to neoadjuvant chemotherapy in patients with muscle-invasive bladder cancer by analyzing genetic and molecular profiles of tumor tissues obtained through transurethral bladder tumor resection.
Conditions
Conditions (1)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Muscle-invasive Bladder Cancer | — | UNRESOLVED | — |
Interventions
Interventions (1)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| neoadjuvant chemotherapy followed by radical cystectomy | Other | — | UNRESOLVED |
Design
Arms and outcomes
Arms (2)
- label
- Platinum-based Neoadjuvant Chemotherapy Sensitive Patients
- description
- Patients with newly confirmed muscle-invasive bladder cancer who have favorable treatment response to platinum-based neoadjuvant chemotherapy
- interventionNames
- Other: neoadjuvant chemotherapy followed by radical cystectomy
- label
- Platinum-based Neoadjuvant Chemotherapy Resistant Patients
- description
- Patients with newly confirmed muscle-invasive bladder cancer who have unfavorable treatment response to platinum-based neoadjuvant chemotherapy
- interventionNames
- Other: neoadjuvant chemotherapy followed by radical cystectomy
Primary outcomes (1)
- measure
- Identification of responder to neoadjuvant chemotherapy by genetic and molecular profiles
- timeFrame
- At the end of 2 cycles of neoadjuvant chemotherapy (each cycle is 14 days (for ddMVAC) / 28 days (for GC))
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 18 Years
- Maximum age
- 80 Years
Show eligibility criteria text
Inclusion criteria: * Suspicious of bladder cancer scheduled to have transurethral resection of bladder tumor * Consent to the provision of their biospecimen. * Willing to cooperate with this study and comply with the restrictions. * Voluntarily signed the consent form for participation in the study. * Age ≥18. Exclusion criteria: * Do not agree with this study. * Vulnerable participants
References
Publications (0)
Data not yet available