Clinical trial · Observational
ERAS for Gastric Cancer Patients After NACT
Short- and Long-term Outcomes Following Perioperative ERAS Management in Patients Undergoing Minimally Invasive Radical Gastrectomy After Neoadjuvant Chemotherapy: A Single-center Retrospective Propensity Score Matching Cohort Study
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
Background: Gastric cancer patients receiving neoadjuvant chemotherapy (NACT) are more vulnerable to perioperative stress. Enhanced recovery after surgery (ERAS) is widely used in surgical patients aiming at reducing stress responses. However, whether this approach is safe and feasible for gastric cancer patients received minimally invasive radical gastrectomy after NACT remained determined. So, the objective of this study is to investigate the effects of ERAS for this special group of gastric cancer patients. Materials and Methods: The data of gastric cancer patients who underwent minimally invasive radical gastrectomy after NACT were collected in this retrospective cohort study. Patients were divided into an ERAS group and a conventional group based on whether they received perioperative ERAS management. Propensity score matching was conducted to eliminate bias. Pre- and postoperative inflammatory and nutritional marker levels, postoperative complications, recovery indices and 3-year OS and RFS were observed.
Conditions
Conditions (1)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Gastric Cancer | Malignant Gastric Neoplasm | CURATED_BROADER | 0.80 |
Interventions
Interventions (2)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| conventional perioperative management | Other | — | UNRESOLVED |
| enhanced recovery after surgery | Other | — | UNRESOLVED |
Design
Arms and outcomes
Arms (2)
- label
- ERAS group
- interventionNames
- Other: enhanced recovery after surgery
- label
- Conventional group
- interventionNames
- Other: conventional perioperative management
Primary outcomes (1)
- measure
- postoperative infectious complications
- timeFrame
- up tp 30 days after surgery
- description
- The primary outcome was the incidence of postoperative infectious complications, which were defined as bacterial infections within 30 d after surgery. The diagnosis of infectious complications was based on fever (≥38°C), elevation of C-reactive protein (CRP), specific clinical symptoms of infection, and positive bacterial culture.
Secondary outcomes (4)
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 18 Years
- Maximum age
- 80 Years
Show eligibility criteria text
Inclusion Criteria: * gastric adenocarcinoma confirmed by histopathology, * received 2 to 4 cycles of NACT before surgery, * minimally invasive (DaVinci or laparoscopy) radical gastrectomy with D2 lymph node dissection Exclusion Criteria: * conversion to open surgery due to intraoperative difficulties or uncontrolled complications (for example, intraoperative massive bleeding), * inability to complete the planned preoperative chemotherapy, * infeasibility of performing radical gastrectomy during surgery * ERAS item implementation rate less than 60%
References
Publications (0)
Data not yet available