WoW - Single- vs Two-staged Excisions of Thin Melanoma

Inclusion Criteria:

Patients need to fulfill all criteria listed below:

* Has recently been diagnosed with a primary invasive cutaneous melanoma of Breslow thickness ≤1.0 mm (pT1) as determined by a diagnostic excision with subsequent histopathological analysis that:

  1. Is located on a body location in which a WLE with a 10-mm clinical margin is feasible and would have been planned according to current standard of care.
  2. Had histopathologically verified free margins of at least 1.5 mm.
* Is 18 years or older at time of consent.
* Is able to give informed consent and comply with the treatment protocol and follow-up plan.
* Has a life expectancy of ≥5 years from the time of diagnosis.

Exclusion Criteria:

If any of the listed criteria below are present, the patient is ineligible for study participation.

The study lesion:

* was partially biopsied prior to the diagnostic excision.
* was diagnostically excised with a clinical margin \>5 mm.
* was a melanoma of desmoplastic or lentiginous (i.e. lentigo maligna or acral lentiginous) subtype.
* was located on digits in which amputation is necessary.

The patient:

* had a previous or concurrent MIS or invasive melanoma (cutaneous or non-cutaneous).
* had physical, clinical, radiographic or pathologic evidence of microsatellite, satellite, in-transit, regional or distant metastatic melanoma.
* had a previous or intercurrent treated solid tumor or hematologic malignancy during the past 5 years except cutaneous squamous cell carcinoma or basal cell carcinoma.
* has planned adjuvant radiotherapy to the primary melanoma site after WLE.