Clinical trial · Observational
Improving the Success Rate for Thoracic Radiotherapy Through Specific Cardiac Substructure Dosimetry: Location Matters. (LOCATION MATTERS)
"Improving the Success Rate for Thoracic Radiotherapy Through Specific Cardiac Substructure Dosimetry: Location Matters - a Prospective Study"
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
The prospective study LOCATION MATTERS aims to investigate the radiation-induced damage to the heart and the cardiovascular system in patients treated with thoracic radiotherapy. Patients enrolled in the study will complete a set of extensive measures at the baseline, end of RT, and 9 months after treatment. Ultrasound exams, CT scans, pulmonary tests and wearable devices will assess functional and morphological parameters and the association with their variation and the dose delivered to the heart substructures and to the normal lung.
Conditions
Conditions (1)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Locally Advanced Lung Non-Small Cell Carcinoma | Lung Non-Small Cell Carcinoma | CURATED_BROADER | 0.80 |
Interventions
Interventions (0)
Data not yet available
Design
Arms and outcomes
Arms (0)
[]Primary outcomes (1)
- measure
- Variation in eco-cardio and eco-vascular parameters after thoracic radiotherapy
- timeFrame
- Baseline - End RT - 9 months after RT completion
- description
- A set of ultrasound parameters will be normalised to the individual patient value at the baseline. We will evaluate an acute reaction (end of RT) and a late reaction/recovery assessment at 9 months after RT
Secondary outcomes (2)
- measure
- Major adverse cardiac events post-RT
- timeFrame
- Baseline - End RT - 9 months after RT completion
- description
- MACEs will be evaluated and recorded during patient FU as a no/yes variable
- measure
- Increase in cardiac calcification after RT
- timeFrame
- Baseline - End RT - 9 months after RT completion
- description
Eligibility
Eligibility (as posted)
- Sex
- All
Show eligibility criteria text
Inclusion Criteria: * Patients with NSCLC * Patients with locally advanced disease (Stage 3) * Patients treated with RT at Fondazione IRCCS Istituto Nazionale dei Tumori Exclusion Criteria: * Previous thoracic radiotherapy * Previous heart surgery
References
Publications (0)
Data not yet available