Clinical trial · Observational
Fertility Preservation and Pregnancy and Offspring Health Outcomes in Female Cancer
Fertility Preservation and Pregnancy and Offspring Health Outcomes in Female Cancer Patients: A Multicenter, Prospective, Cohort Study
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
To explore whether there is a significant difference in the cumulative live birth rate and maternal and child health outcomes between cancer patients who undergo or do not undergo fertility preservation before receiving anti-tumor treatment and non-cancer patients who undergo assisted reproductive technology treatment/natural pregnancy. This study will be conducted in the Clinical Center of Reproductive Medicine, First Affiliated Hospital of Nanjing Medical University. 2800 women diagnosed with malignant cancers who has desire to reproduce will be enrolled in this study. Statistical analysis of the data will be performed.
Conditions
Conditions (2)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Cancer | Malignant Neoplasm | ALIAS | 0.90 |
| Fertility Issues | — | UNRESOLVED | — |
Interventions
Interventions (1)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| fertility preservation | Other | — | UNRESOLVED |
Design
Arms and outcomes
Arms (2)
- label
- Fertility preservation
- description
- patients who choose fertility preservation
- interventionNames
- Other: fertility preservation
- label
- Observation
- description
- patients who choose observation
Primary outcomes (1)
- measure
- 5-year cumulative live birth rate
- timeFrame
- 5 years
- description
- 5-year cumulative live birth rate for female patients who reproduce
Secondary outcomes (5)
- measure
- Ovarian function(AMH levels)
Eligibility
Eligibility (as posted)
- Sex
- Female
- Minimum age
- 20 Years
- Maximum age
- 40 Years
Show eligibility criteria text
Inclusion Criteria: 1. Tumor confirmed (main focus: breast cancer, hematological disease/lymphoma, gynecological tumor (ovarian cancer), boundary tumors, nasopharyngeal cancer, colorectal cancer, and other tumors that require anti-tumor treatment; 2. Having a desire for future fertility(including women who have already given birth); 3. Age: 20-40 years old (patients planning to freeze their eggs are ≤35 years old, and those planning to freeze their embryos are ≤40 years old); 4. Consent. Exclusion Criteria: 1. Patients with congenital or acquired uterine abnormalities, severe intrauterine adhesions, and other diseases that have a clear impact on pregnancy; 2. Those with assisted reproductive technology and pregnancy contraindications; 3. Tumors that are not suitable for pregnancy after multidisciplinary discussions on tumor fertility; 4. Clinical diagnosis of POI (premature ovarian insufficiency).
References
Publications (0)
Data not yet available