Clinical trial · Observational
Extent of Intrahepatic Infiltration of Perihilar Cholangiocarcinoma
Pattern and Extent of Intrahepatic Infiltration of Perihilar Cholangiocarcinoma - A Liver Panoramic Digital Pathological Study
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
The extent of intrahepatic infiltration of perihilar cholangiocarcinoma (PHCC) remains unclear. This research aimed to explore the pattern and extent of intrahepatic infiltration of PHCC to guide surgical treatment and pathological research. This prospective study included 62 participants diagnosed with PHCC who underwent major hepatectomy. A whole-mount digital liver pathology system (WDLPS) for hepatectomy specimens greater than 10 × 10 cm was used to panoramically assess the intrahepatic infiltration extent of PHCC.
Conditions
Conditions (1)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Perihilar Cholangiocarcinoma | Hilar Cholangiocarcinoma | ALIAS | 0.90 |
Interventions
Interventions (0)
Data not yet available
Design
Arms and outcomes
Arms (2)
- label
- No RLI vs RLI
- description
- No RLI: PHCC patients without RLI. RLI: PHCC patients with RLI.
- label
- No DIHI vs DIHI
- description
- No DIHI: PHCC patients without DIHI. DIHI: PHCC patients with DIHI.
Primary outcomes (1)
- measure
- Relapse-free survival (RFS).
- timeFrame
- RFS as of December 2023
- description
- Refers to the survival time of a PHCC patient without recurrence of PHCC for a period of time after surgical treatment.
Secondary outcomes (1)
- measure
- Overall survival (OS).
- timeFrame
- OS as of December 2023
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 44 Years
- Maximum age
- 81 Years
Show eligibility criteria text
Inclusion Criteria: 1. Patients were diagnosed for PHCC based on clinical manifestations, imaging, and pathological findings. 2. Hepatectomy was performed. 3. WDLPS was successfully produced. Exclusion Criteria: 1. Not PHCC patients. 2. Patients with PHCC did not undergo hepatectomy. 3. WDLPS was not successfully produced.
References
Publications (1)
- DERIVEDJin S, Jiang N, Zhao JM, Xiao Y, Wang SY, Xiang CH, Lu Q, Shan SQ, Ruan HT, Yu SQ, Zeng JP, Yang SZ, Li L, Dong JH. Pattern and extent of intrahepatic infiltration of perihilar cholangiocarcinoma - a case-control study based on liver panoramic digital pathology. Int J Surg. 2025 Jan 1;111(1):31-39. doi: 10.1097/JS9.0000000000002040. PMID 39166939