Clinical trial · Observational
A Risk Prediction Model of Postoperative Nausea and Vomiting in Patients With Liver Cancer
Development and Validation of a Machine Learning Model for Postoperative Nausea and Vomiting in Patients With Liver Cancer
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
PONV management has been recommended as a necessary part of enhanced recovery protocols during the perioperative period, and PONV risk assessment is, therefore, a necessary first step in determining the number of medications or strategies for prophylaxis and treatment by considering the number of modifiable and non-modifiable risk factors. However, the external validity of two commonly-used PONV prediction models for patients undergoing liver surgery is unsatisfied, and need to be updated for liver cancer populations to better inform personalized perioperative care regime and individualized decision-making in clinical practice.
Conditions
Conditions (2)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Liver Cancer | Malignant Liver Neoplasm | CURATED_EXACT | 0.92 |
| Nausea and Vomiting, Postoperative | — | UNRESOLVED | — |
Interventions
Interventions (1)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| 1 | Other | — | UNRESOLVED |
Design
Arms and outcomes
Arms (2)
- label
- patients with PONV
- interventionNames
- Other: 1
- label
- patients without PONV
Primary outcomes (1)
- measure
- Postoperative nausea and vomiting
- timeFrame
- Postoperative nausea and vomiting will be assessed every hour during the first two hours, every two hours for the following four hours and every four hours until the 24th hour
- description
- PONV will be evaluated on a four-grade scale from 0 (no nausea and no vomiting), 1 (having nausea but no vomiting), 2 (having vomiting without stomach contents) to 3 (having vomiting with stomach contents).
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 18 Years
- Maximum age
- 80 Years
Show eligibility criteria text
Inclusion Criteria: * Patients who are diagnosed with liver cancer and underwent hepatectomy * Patients who are older than 18 years * Patients who have planned admissions and elective surgery, and stay at least 24 hours in the surgical unit. Exclusion Criteria: * Patients with cognitive impairment * Patients with nausea and vomiting related to other existing diseases, such as gastroesophageal reflux disease. * Patients with severe postoperative complications, including massive abdominal hemorrhage, hepatic encephalopathy and portal vein thrombosis.
References
Publications (0)
Data not yet available