Clinical trial · Interventional
Adaptive Variable-Resistance Training in Pediatric Survivors of Acute Lymphoblastic Leukemia
Effects of Adaptive Variable-resistance Training on Chemotherapy-induced Sarcopenia, Fatigue, and Functional Restriction in Pediatric Survivors of Acute Lymphoblastic Leukemia: A Large-scale Randomized Controlled Trial
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
This study was designed to investigate the effect of eight weeks of adaptive variable-resistance training (Adaptive-VRT) on chemotherapy-induced sarcopenia, fatigue, and functional restrictions in a convenience sample of pediatric survivors of acute lymphoblastic leukemia (ALL). Sixty-two pediatric survivors of ALL were randomly allocated to the experimental group (n = 31, received the adaptive variable-resistance training) or the Control group (n = 31, received standard physical therapy care). Both groups were assessed for muscle mass, strength, fatigue, and functional capacity before and after treatment.
Conditions
Conditions (1)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Acute Lymphoblastic Leukemia | Acute Lymphoblastic Leukemia | ONTOLOGY_EXACT | 0.98 |
Interventions
Interventions (2)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| Adaptive variable-resistance training | Other | — | UNRESOLVED |
| Standard physical therapy | Other | — | UNRESOLVED |
Design
Arms and outcomes
Arms (2)
- type
- EXPERIMENTAL
- label
- Adaptive-VRT
- description
- Participants in this group received the adaptive variable-resistance training program in besides the standard physical therapy care.
- interventionNames
- Other: Adaptive variable-resistance training
- type
- ACTIVE_COMPARATOR
- label
- Standard Physical Therapy
- description
- Participants in this group received the standard exercise program.
- interventionNames
- Other: Standard physical therapy
Primary outcomes (2)
- measure
- Thigh muscle thickness
- timeFrame
- 2 months
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 12 Years
- Maximum age
- 18 Years
Show eligibility criteria text
Inclusion Criteria: * Age between 12 and 18 years old * Complete maintenance chemotherapy * Secondary sarcopenia * Normal cardiac structure and function * Absence of lower limb deformities * Not engaging in regular exercise regimens Exclusion Criteria: * Secondary cancers * Neurodegenerative impairments affecting memory, attention, or executive functioning * Neuro-musculoskeletal conditions are likely to impede the training.
References
Publications (1)
- DERIVEDElnaggar RK, Mahmoud WS, Abdrabo MS, Elfakharany MS. Effect of adaptive variable-resistance training on chemotherapy-induced sarcopenia, fatigue, and functional restriction in pediatric survivors of acute lymphoblastic leukemia: a prospective randomized controlled trial. Support Care Cancer. 2025 Feb 22;33(3):214. doi: 10.1007/s00520-025-09250-x. PMID 39985582