Clinical trial · Observational
PPIO-007 Correlation Analysis of Type II Diabetes Mellitus on Short-term and Long-term Outcomes of Patients With Esophageal Squamous Cell Cancer Undergoing Minimally Invasive Esophagectomy
Correlation Analysis of Type II Diabetes Mellitus on Short-term and Long-term Outcomes of Patients With Esophageal Squamous Cell Cancer Undergoing Minimally Invasive Esophagectomy
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
To date, there is controversy as to whether type II diabetes mellitus is associated with adverse short- and long-term outcomes in patients with esophageal squamous cell carcinoma undergoing minimally invasive esophagectomy. At the same time, to the best of our knowledge, the impact of metformin use and glycemic control on short- and long-term outcomes in this patient population is also controversial. Therefore, this study aims to test the hypothesis that diabetes mellitus is associated with reduced survival in patients with esophageal squamous cell carcinoma undergoing minimally invasive esophagectomy and that treatment with metformin and/or good glycemic control (HbA1c\<7.0%) is associated with improved survival.
Conditions
Conditions (2)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Esophageal Squamous Cell Carcinoma | Esophageal Squamous Cell Carcinoma | ONTOLOGY_EXACT | 0.98 |
| Surgery | — | UNRESOLVED | — |
Interventions
Interventions (1)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| Whether there is type 2 diabetes mellitus before surgery | Other | — | UNRESOLVED |
Design
Arms and outcomes
Arms (2)
- label
- Coe-T2DM group
- description
- There was a definitive diagnosis of type 2 diabetes mellitus before surgery
- interventionNames
- Other: Whether there is type 2 diabetes mellitus before surgery
- label
- No-T2DM group
- description
- There was no clear diagnosis of type 2 diabetes mellitus before surgery
Primary outcomes (2)
- measure
- Overall survival
- timeFrame
- About five years postoperatively
- description
- Overall survival (OS) was defined as the time from the date of surgery to death from any cause or last follow-up.
- measure
- Disease-free survival
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 18 Years
- Maximum age
- 80 Years
Show eligibility criteria text
Inclusion Criteria: 1. Patients with a clear pathologic diagnosis of esophageal squamous cell carcinoma; 2. Received minimally invasive McKeown procedure; 3. Patients with R0 resection (R0: radical resection). Exclusion Criteria: 1. Concomitant history of other primary cancers or other cancers; 2. Distant metastases before surgery; 3. Serious comorbidities of other systems before surgery; 4. Patients diagnosed with T2DM during follow-up; 5. The medical record information is incomplete.
References
Publications (1)
- DERIVEDPu XS, Wu YQ, Bao T, Li KK, He XD, He Y, Chen X, Li CF, Wang YJ, Guo W. Type 2 diabetes mellitus confers unfavorable short- and long-term outcomes in patients undergoing esophagectomy. Surg Endosc. 2026 Jul 23. doi: 10.1007/s00464-026-13136-2. Online ahead of print. PMID 42493614