Clinical trial · Observational
A Comparative Study Between Early Onset Colorectal Cancer and Late Onset Colorectal Cancer Patients
Early-Onset Colorectal Cancer Versus Late-Onset Colorectal Cancer: a Prospective Observational Cohort Study to Explore the Clinical, Sociodemographic, Genetic, and Molecular Characteristics Associated With Adverse Oncological Outcomes (
NCT06326879CI-TRIAL-00075378EOrOSrecruitingClinicalTrials.gov clinicaltrialsProvenance
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
This study aims to investigate the clinical, socioeconomic, behavioral, genetic, and molecular factors characterizing Early Onset Colorectal Cancer (EOCRC) patients compared with Late Onset Colorectal Cancer (LOCRC) patients
Conditions
Conditions (1)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Colorectal Cancer | Malignant Colorectal Neoplasm | CURATED_BROADER | 0.80 |
Interventions
Interventions (1)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| No intervention | Other | — | UNRESOLVED |
Design
Arms and outcomes
Arms (2)
- label
- Early Onset Colorectal Cancer (EOCRC)
- description
- Patients aged less or equal to 49 years old at the time of colorectal cancer diagnosis
- interventionNames
- Other: No intervention
- label
- Late Onset Colorectal Cancer (LOCRC)
- description
- Patients aged more or equal to 50 years old at the time of colorectal cancer diagnosis
- interventionNames
- Other: No intervention
Primary outcomes (1)
- measure
- Incidence rate ratio of colorectal cancer recurrence
- timeFrame
- 24 months after surgery
- description
- Incidence rate ratio of 24-month colorectal cancer recurrence- defined as any radiological or endoscopic evidence of local recurrence or distal metastasis after the index surgery in stage I-III patients- between the study cohorts
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 18 Years
Show eligibility criteria text
Inclusion Criteria: * Patients aged more than 18 years old at the time of inclusion. * Patients with a proven diagnosis of colorectal adenocarcinoma, as reported by the staging histological biopsies. * Patients with a preoperative staging I-III. * Patients scheduled for elective curative colorectal resection. * Patients with rectal cancer who underwent neoadjuvant therapy can be included in the study. * Patients able and willing to comply with the protocol requirements (samples' collection and questionnaires' compilation). Exclusion Criteria: * Patients with metastatic disease at diagnosis. * Patients requiring an emergent procedure. * Patients undergoing palliative surgery (for example, fecal diversion). * Patients with a surgical indication for benign lesions (for example, adenoma or dysplasia). * Patients with an intraoperative finding of a lesion other than adenocarcinoma will be withdrawn from the study. * Patients with an intraoperative finding of distal metastasis or peritoneal carcinosis will be withdrawn from the study. * Patients with a concomitant diagnosis of Inflammatory Bowel Disease. * Patients with a known genetic syndrome (for example, Lynch syndrome or Familial Adenomatous Polyposis).
References
Publications (0)
Data not yet available
No reference posted for this study.