Clinical trial · Observational
Survival Benefit of Primary Tumour Resection Compared to Systemic Therapy Alone in Stage IV Colorectal Cancer Patients
Survival Benefit of Palliative Primary Tumor Resection and Systemic Therapy Versus Systemic Therapy Only Among Patients With Stage IV Colorectal Carcinoma
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
About 20-25 percent of all colorectal cancer patients are diagnosed with International Union Against Cancer (UICC) stage IV disease. The benefit of primary tumor resection in the palliative context is therefore of high concern. However, empirical evidence from randomized and observational studies is inconsistent. The objective of the present study is to compare the survival of palliative stage IV colorectal cancer patients selected for primary tumor resection and systemic treatment (PTR+SYST) to patients with systemic treatment only (SYST).
Conditions
Conditions (2)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Colorectal Cancer | Malignant Colorectal Neoplasm | CURATED_BROADER | 0.80 |
| Neoadjuvant Systemic Therapy | — | UNRESOLVED | — |
Interventions
Interventions (2)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| Primary tumor resection | Procedure | — | UNRESOLVED |
| Systemic Therapy | Procedure | — | UNRESOLVED |
Design
Arms and outcomes
Arms (2)
- label
- SYST
- description
- Systemic treatment only. Systemic treatment was defined as the application of chemotherapy, antibody, or immunotherapy (alone or in combination) starting within 12 months after diagnosis (definition for both groups)
- interventionNames
- Procedure: Systemic Therapy
- label
- PTR+SYST
- description
- primary tumor resection and systemic treatment At least one of the following surgical procedures were performed: German procedure codes OPS 5-455.\*, 5-456.\*, 5-484.\*, 5-485.\*
- interventionNames
- Procedure: Primary tumor resection
- Procedure: Systemic Therapy
Primary outcomes (1)
- measure
- Survival
- timeFrame
- 5-year follow up
- description
Eligibility
Eligibility (as posted)
- Sex
- All
Show eligibility criteria text
Inclusion Criteria: * diagnosed colorectal carcinoma * stage IV * systemic therapy, starting within 12 months after diagnosis Exclusion Criteria: * rectal cancer of the lower two-thirds * emergency procedures * unknown Eastern Cooperative Oncology Group (ECOG) performance status * ECOG\>2 * unknown metastatic status * unclear grading
References
Publications (1)
- DERIVEDMantke R, Schneider C, von Ruesten A, Hauptmann M. Patients with stage IV colorectal carcinoma selected for palliative primary tumor resection and systemic therapy survive longer compared with systemic therapy alone: a retrospective comparative cohort study. Int J Surg. 2024 Oct 1;110(10):6493-6500. doi: 10.1097/JS9.0000000000001838. PMID 38935125