Clinical trial · Observational
Microbiota in Gastric Cancer by Gastric Mucosal Brushing
Microbiota Diversity and Composition in Gastric Cancer by Gastric Mucosal Brushing: a Cross-sectional Case-control Study
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
Many studies have shown a significant change of diversity and composition in gut microbiota across the gastric carcinogenesis process, particularly in patients with gastric cancer. However, there has been no analysis of gastric microbiota using the mucosal brushing technique, despite its favoring benefit in microbiota study. Therefore, this study aims to evaluate microbiota profile in patients with gastric cancer, compared to those without gastric cancer by using mucosal brush sampling. This will improve current knowledge of the potential role of the microbiome in patient gastric cancer as a future biomarker marker using brushing sampling.
Conditions
Conditions (1)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Gastric Cancer | Malignant Gastric Neoplasm | CURATED_BROADER | 0.80 |
Interventions
Interventions (2)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| Gastric mucosal biopsy | Diagnostic Test | — | UNRESOLVED |
| Gastric mucosal brushing | Diagnostic Test | — | UNRESOLVED |
Design
Arms and outcomes
Arms (2)
- label
- Gastric cancer group
- description
- * Adult patients (≥18 years of age) and undergoing esophagogastroduodenoscopy * Patients with pathological diagnosis of high-grade dysplasia or gastric cancer
- interventionNames
- Diagnostic Test: Gastric mucosal brushing
- Diagnostic Test: Gastric mucosal biopsy
- label
- Control group
- description
- * Adult patients (≥18 years of age) and undergoing esophagogastroduodenoscopy * Patients with no or minimal upper GI symptoms and current EGD appear normal or minimal gastritis
- interventionNames
- Diagnostic Test: Gastric mucosal brushing
- Diagnostic Test: Gastric mucosal biopsy
Primary outcomes (1)
- measure
- Microbiome analysis using gastric mucosal brushing
- timeFrame
- Through study completion, estimated 1.5 yr
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 18 Years
Show eligibility criteria text
Inclusion Criteria: * Adult patients (≥18 years of age) and undergoing esophagogastroduodenoscopy (EGD) * Gastric cancer group: patients with pathological diagnosis of high-grade dysplasia or gastric cancer * Control group: patients with no or minimal upper GI symptoms and current EGD appear normal or minimal gastritis * Informed consent obtained Exclusion Criteria: * Had a history of GI or hepatobiliary surgery * Had a history of recent (within 4 weeks) antibiotic or probiotic use * Had a history of PPI use within 2 weeks
References
Publications (0)
Data not yet available