Linperlisib Plus Obinutuzumab and Venetoclax for Relapsed and Refractory Blastoid Variant of Mantle Cell Lymphoma.

Inclusion Criteria:

* Age ≥ 18 years old;
* Mother cell type mantle cell lymphoma (BV-MCL) confirmed by histopathological and immunophenotypic analysis;
* The Eastern Oncology Collaborative Group (ECOG) scored 0-2 on physical fitness status;
* Expected lifespan ≥ 3 months
* There is at least one measurable lesion: the longest diameter (LDi) of lymph node lesions is ≥ 1.5 cm, or the LDi of extralymph node lesions is ≥ 1 cm, or splenomegaly, or bone marrow involvement with or without malignant lymphocytosis;
* Have not received treatment with PI3K inhibitors and BCL-2 inhibitors in the past; Having sufficient bone marrow and organ functions;
* Having sufficient bone marrow and organ functions;
* All screening period laboratory tests must be conducted according to the requirements of the plan, and must be conducted within 7 days before enrollment. The values of laboratory tests conducted for screening must meet the following criteria:

Blood routine examination (no blood transfusion, no use of granulocyte colony-stimulating factor (G-CSF), no medication correction within 14 days prior to screening):

1. Hemoglobin (Hb) ≥ 80 g/L;
2. Neutrophils (ANC) ≥ 1.0 × 109/L;
3. Platelet count (PLT) ≥ 75 × 109/L;

Biochemical examination:

1. TBIL\<1.5 × Upper limit of normal range (ULN);
2. Glutamate alanine aminotransferase (ALT) and aspartate aminotransferase (AST) ≤ 2.5 × ULN;
3. Serum creatinine (Cr) ≤ 1.25 × ULN or endogenous creatinine clearance rate ≥ 60 mL/min (Cockcroft Gault formula);

Coagulation function (unless the subject is receiving anticoagulant therapy and the coagulation parameters (PT/INR and APTT) are within the expected range of anticoagulant therapy at the time of screening):

1. International normalized ratio (INR) ≤ 1.5 × ULN;
2. Activated partial thromboplastin time (APTT) ≤ 1.5 × ULN;

   * Those who have not participated in clinical trials of other drugs within the 4 weeks prior to enrollment;
   * Women with a possibility of pregnancy must undergo a serum pregnancy test within 7 days before the first medication, and the result is negative. They are willing to Intended to use efficient methods of contraception during the trial period and within 1 year after the last administration of the investigational drug. For male subjects whose partners are women of childbearing age, they should undergo surgical sterilization or agree to use high-efficiency contraception methods during the trial period and 1 year after the last administration of the trial drug;
   * The subjects voluntarily joined this study, signed an informed consent form, had good compliance, and cooperated with follow-up.

Exclusion Criteria:

* Patients who have received any targeted PI3K or BCL treatment before enrollment;
* History of other primary invasive malignant tumors that have not been relieved or have not been relieved for more than 3 years;
* Those with involvement of the central nervous system (meninges or brain parenchyma);
* Individuals who are known to have allergies to any medication in the study;
* Participated in clinical trials of other drugs within 4 weeks prior to the start of the study;
* Pregnant or lactating women;
* Individuals with active infections, excluding fever related to tumor B symptoms;
* Concomitant diseases and medical history:

  1. There are multiple factors that affect oral medication, such as inability to swallow, chronic diarrhea, and intestinal obstruction
  2. Individuals with a history of psychiatric drug abuse who are unable to quit or have mental disorders;
  3. Subjects with any severe and/or uncontrolled diseases, including:

     1. Poor blood pressure control (systolic blood pressure ≥ 150 mmHg or diastolic blood pressure ≥ 100 mmHg);
     2. Suffering from ≥ grade 2 myocardial ischemia or myocardial infarction, arrhythmia \[including QTc ≥ 450ms (male), QTc ≥ 470ms (female)\], and ≥ grade 2 congestive heart failure \[NYHA classification\];
     3. Active interstitial pneumonia or other chronic lung diseases leading to severe impairment of lung function, defined as FEV1 and DLCOc\<60% of normal predicted values;
     4. Liver abnormalities;
     5. Decompensated cirrhosis (Child Pugh liver function rating of B or C)
     6. Known clinically significant history of liver disease. Including viral hepatitis, known carriers of hepatitis B virus (HBV) must exclude active HBV infection, i.e. HBV DNA positivity (\>2500 copies/mL or\>500 IU/mL, and above the upper limit of normal values); Known hepatitis C virus infection (HCV) and HCV RNA positivity (\>1×103copies/mL). Note: hepatitis B HBsAg positive subjects who meet the inclusion conditions, whether their HBV DNA is measurable or not, need to continue antiviral treatment (nucleoside analogues are recommended) and regularly monitor HBV DNA; For subjects with positive HBcAb but negative HBsAg in hepatitis B, HBV DNA should be monitored regularly and preventive antiviral treatment should be recommended; Hepatitis C patients need to regularly monitor HCV RNA.
     7. Renal failure requiring hemodialysis or peritoneal dialysis;
     8. Subjects with uncontrolled pleural effusion, pericardial effusion, or ascites that require repeated drainage;
     9. Poor control of diabetes (FBG\>10 mmol/L);
     10. Urine routine indicates urine protein ≥++, and it is confirmed that the 24-hour urine protein quantification is greater than 1.0 g;
* Have a history of immunodeficiency, including HIV testing positive, or other acquired or congenital immunodeficiency diseases, or a history of organ transplantation;
* According to the researcher's judgment, there are accompanying diseases that seriously endanger patient safety or affect patient completion of the study. Unable to understand the nature of the research or disagrees to sign an informed consent form;
* The researcher evaluates other situations that are not suitable for inclusion in the study.