Clinical trial · Interventional
RealMove (Lung): Assessing Tumour Motion With Dynamic MRI
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
The study aims to develop an improved method to tailor the geometric safety margin when treating with stereotactic body radiotherapy (SBRT), to avoid tumour cells being missed during irradiation and to limit the exposure of normal tissues as much as possible. Dynamic magnetic resonance imaging (MRI) is assumed to represent the tumour motion during the respiratory cycle more realistically, compared to 4-dimensional computed tomography (4D CT), thanks to its high temporal resolution and the possibility to image the motion over a longer period of time. Patients receiving SBRT for a pulmonary target located below the level of the carina are included in the study, and the hypothesis will be tested through a comparison of the tumour amplitude measured with each modality. Furthermore, the predictive value of the image series acquired at treatment planning, for the motion patterns observed at each treatment fraction, will be evaluated through repeated 4D CBCT acquisitions.
Conditions
Conditions (1)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Lung Tumor | Lung Neoplasm | ALIAS | 0.90 |
Interventions
Interventions (1)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| Dynamic MRI | Other | — | UNRESOLVED |
Design
Arms and outcomes
Arms (1)
- type
- EXPERIMENTAL
- label
- Full cohort
- description
- All subjects are included in the same arm.
- interventionNames
- Other: Dynamic MRI
Primary outcomes (3)
- measure
- Difference in amplitude of the tumour motion, as assessed by dynamic MRI and 4D CT, respectively
- timeFrame
- Over 3-4 weeks: twice pre-treatment, and three times during treatment
- description
- The two dynamic scans represent the tumour motion through different techniques. If the amplitude indicated by 4D CT is smaller than that indicated by dynamic MRI, the hypothesis is confirmed.
- measure
- Difference in amplitude of the tumour motion, assessed at different times (using dynamic MRI and 4D CBCT)
- timeFrame
- Over 3-4 weeks: twice pre-treatment, and three times during treatment
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 18 Years
Show eligibility criteria text
Inclusion Criteria: * Accepted for SBRT treatment of one or more caudally situated lung targets (NSCLC or metastases), i.e. below the carina. * Age ≥ 18 years * Adequate clinical condition to maintain immobilised position for at least 30 minutes * Adequate Swedish skills and cognitive function to understand study information and to fill in the questionnaire Exclusion Criteria: * Pregnancy or breastfeeding, or planned pregnancy or breastfeeding, during treatment * Contraindication for MRI examination * Otherwise incapable of participating in study
References
Publications (0)
Data not yet available