Clinical trial · Observational
Implication of CCR4-NOT Complex Subunit 7 Expression in Natural Killer Cell Resistance in Metastatic Breast Cancer
CNOT7 Blood Level and Correlation to LAIR-1 in Metastatic vs Non-metastatic Breast Cancer Egyptian Patient's Cohort; a Case-Controlled Mechanistic Study
NCT06320392CI-TRIAL-00079314CCR4-NOTcompletedClinicalTrials.gov clinicaltrialsProvenance
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
Being a mechanistic study, this work aims to figure out "the role of the cytoplasmic mRNA deadenylase CNOT7 expressed protein on NK cell resistance in metastatic BC". In other words, to explore, whether, "CNOT7 contributes to metastasis in Egyptian female metastatic BC patient's cohort, through NK cell resistance, or not."
Conditions
Conditions (1)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Metastatic Breast Cancer | Malignant Breast Neoplasm | CURATED_BROADER | 0.78 |
Interventions
Interventions (0)
Data not yet available
No intervention recorded.
Design
Arms and outcomes
Arms (2)
- label
- metastatic
- description
- 44 female BC patients, volunteered in the study, diagnosed with metastatic BC. Patients were enrolled randomly from the Clinical Oncology Department, Faculty of Medicine, Mansoura University Hospitals, Mansoura University, Mansoura, Egypt, after signing the IC.
- label
- non-metastatic
- description
- 46 female BC patients, volunteered in the study, diagnosed with primary naive (non-metastatic) invasive BC . Patients were enrolled randomly from the Clinical Oncology Department, Faculty of Medicine, Mansoura University Hospitals, Mansoura University, Mansoura, Egypt, after signing the IC.
Primary outcomes (3)
- measure
- Cytoplasmic mRNA deadenylase CNOT7 protein expression level in metastatic/advanced localized and non-metastatic BC sera using ELISA.
- timeFrame
- 12 months
- measure
- CNOT7 tissue expression level in BC tissue samples categorized as metastatic vs non-metastatic tumor alongside with adjacent non-tumor tissue margin using immunohistochemistry.
Eligibility
Eligibility (as posted)
- Sex
- Female
Show eligibility criteria text
Inclusion Criteria: * Adults over 18 years old with breast carcinoma of no special type (NST) confirmed pathologically. Exclusion Criteria: * breast cancer patients with blood disorders * breast cancer patients with any cancer other than BC * breast cancer patients with liver cirrhosis * breast cancer patients with uterine or urinary bladder diseases * breast cancer patients with incomplete data or incomplete histopathology diagnosis report
References
Publications (0)
Data not yet available
No reference posted for this study.