Clinical trial · Observational
Immune Function of Colorectal Cancer Lymph Nodes
A Multiomics-based Study of the Immune Function of Colorectal Cancer Lymph Nodes
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
Lymph nodes are very important immune organs in the human body and play an important role in the physiological and pathological activities of the body, especially in anti-tumor immunity. The role of regional draining lymph nodes in the development of colorectal cancer is still unknown. In this study, the role of lymph nodes in the development of colorectal cancer was investigated through multicenter and multi-omics data.
Conditions
Conditions (2)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Colorectal Cancer | Malignant Colorectal Neoplasm | CURATED_BROADER | 0.80 |
| Lymph Node | — | UNRESOLVED | — |
Interventions
Interventions (0)
Data not yet available
Design
Arms and outcomes
Arms (2)
- label
- negative lymph node
- label
- postive lymph node
Primary outcomes (3)
- measure
- To investigate the difference of immune pathway activation in tumor-draining lymph node based on genomics
- timeFrame
- 2024.04-2026.04
- description
- BULK-RNA sequencing was performed on tumor draining lymph nodes to detect the activation of immune pathways in lymph nodes and explore the differences between them
- measure
- To investigate the relationship between the type and number of immune cells in tumor draining lymph nodes and the activation of immune pathways is based on pathomics
- timeFrame
- 2024.04-2026.04
- description
- Multiple immunohistochemistry was used to identify the type and number of immune cells and to explore the relationship between the activation state of immune pathways
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 18 Years
- Maximum age
- 75 Years
Show eligibility criteria text
Inclusion Criteria: * Stage I-III colorectal cancer patients undergoing radical surgery * Complete imaging, pathology and genetics multi-omics data available * 18-75 years old Exclusion Criteria: * Patients with preoperative neoadjuvant therapy * Patients with incomplete clinical information * Patients with other malignant tumors * Patients with acute infections or untreated chronic infections
References
Publications (0)
Data not yet available