Clinical trial · Observational
Transanal Transection and Single-stapled Anastomosis (TTSS) in Rectal Cancer Patients
Postoperative and Long-term Outcomes of Transanal Tran-section and Single-stapled Anastomosis (TTSS) in Rectal Can-cer Patients: a Multicentric International IDEAL Stage 2b Prospective Parallel Cohort Study
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
The Transanal Transection and Single-Stapled anastomosis (TTSS) technique may be a valid alternative to traditional double-stapled anastomosis for low rectal cancer surgery. This study aims to compare the postoperative and functional outcomes of patients receiving TTSS and traditional double-stapled anastomosis.
Conditions
Conditions (2)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Rectal Cancer | Malignant Rectal Neoplasm | CURATED_EXACT | 0.92 |
| Surgery | — | UNRESOLVED | — |
Interventions
Interventions (2)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| Double-stapled Total Mesorectal Excision (TME) | Procedure | — | UNRESOLVED |
| Transanal Transection and Single-Stapled anastomosis (TTSS) | Procedure | — | UNRESOLVED |
Design
Arms and outcomes
Arms (2)
- label
- Transanal Transection and Single-Stapled anastomosis (TTSS)
- description
- Patients will undergo rectal cancer surgery through low rectal resection with Transanal Transection and Single-Stapled anastomosis (TTSS)
- interventionNames
- Procedure: Transanal Transection and Single-Stapled anastomosis (TTSS)
- label
- Double-stapled Total Mesorectal Excision (TME)
- description
- Patients will undergo rectal cancer surgery through low rectal resection with double-stapled anastomosis Total Mesorectal Excision (TME)
- interventionNames
- Procedure: Double-stapled Total Mesorectal Excision (TME)
Primary outcomes (1)
- measure
- Rate of anastomotic leak
- timeFrame
- 90 days after surgery
- description
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 18 Years
Show eligibility criteria text
Inclusion Criteria: * Adult (≥ 18 years old) patients, men and women, diagnosed with rectal cancer scheduled for elective rectal resection with Total Mesorectal Excision (TME) with double-stapled or Transanal Transection and Single-Stapled anastomosis (TTSS) approaches. * Patients scheduled for open, laparoscopic, or robotic surgery. * Patients preoperatively indicated for sphincter-saving procedures with or without protective-stoma. Exclusion Criteria: * Immediate or delayed hand-sewn coloanal anastomosis. * Patients requiring abdominoperineal resection (APR). Patients undergoing unplanned non-reconstructive surgery will be withdrawn from the study. * Patients with concurrent or previous invasive pelvic malignant tumors. Patients with an intraoperative evidence of invasive pelvic malignant tumors will be withdrawn from the study.
References
Publications (0)
Data not yet available