Clinical trial · Interventional
Open Versus Laparoscopic Ablation of Liver Malignancies
Laparoscopic Versus Open Ablation of Liver Malignancies: a Randomized, Controlled Multicenter Trial
NCT06304766CI-TRIAL-00074980OPTIMALunknownN/AClinicalTrials.gov clinicaltrialsProvenance
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
The purpose of this study is to compare laparoscopic ablation to open ablation of liver malignancies regarding complication rates and ablation response as well as quality of life following the surgery.
Conditions
Conditions (3)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Cholangiocarcinoma | Cholangiocarcinoma | ONTOLOGY_EXACT | 0.98 |
| Hepatocellular Carcinoma | Hepatocellular Carcinoma | ONTOLOGY_EXACT | 0.98 |
| Liver Metastases | — | UNRESOLVED | — |
Interventions
Interventions (2)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| Laparoscopic ablation | Procedure | — | UNRESOLVED |
| Open ablation | Procedure | — | UNRESOLVED |
Design
Arms and outcomes
Arms (2)
- type
- ACTIVE_COMPARATOR
- label
- Open ablation
- description
- Laparotomy performed for open ablation of the tumor
- interventionNames
- Procedure: Open ablation
- type
- EXPERIMENTAL
- label
- Laparoscopic ablation
- description
- Ablation of the tumor performed by laparoscopic approach
- interventionNames
- Procedure: Laparoscopic ablation
Primary outcomes (1)
- measure
- Complications measured by the comprehensive complication index.
- timeFrame
- Complications are registered and clavien-dindo graded 30 days after surgery.
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 18 Years
Show eligibility criteria text
Inclusion Criteria: * One or more tumors not amenable to percutaneous ablation, age ≥ 18, signed informed consent, diagnosis of primary liver cancer or liver metastases from any primary tumor, and tumor suitable for ablation as primary treatment. Exclusion Criteria: * Ablation performed in conjunction with resection, patients who cannot cooperate with the study, and patients who do not understand or speak Danish.
References
Publications (1)
- DERIVEDKnofler LA, Klubien J, Larsen PN, Kiim KS, Fukumori D, Tschuor C, Nielsen SD, Pommergaard HC. Open versus laparoscopic ablation of liver malignancies - a protocol for a randomised clinical trial. Dan Med J. 2026 Jan 14;73(2):A04250305. doi: 10.61409/A04250305. PMID 41736646