TGRX-326 Pharmacokinetic Drug Interaction

Inclusion Criteria:

* healthy subject; male or female
* Age between 18 and 45 (inclusive)
* body mass index (BMI) between 19.0 and 26.0 (inclusive)
* agree to consent
* able to communicate with investigator well and complete the study according to study protocol

Exclusion Criteria:

* abnormal and clinically significant test results (including physical exam, laboratory tests, 12-lead ECG, chest x-ray, etc.)
* any one positive result for hepatitis-B surface antigen, Hepatitis C antibody, HIV antibody or syphilis antibody
* prolongation in QT interval
* use of substance that affects CYP3A4 enzyme activity with 30 days before screening
* use of any drug within 14 days of test article administration
* use of any investigational drug or participation of any clinical study within 3 months before screening
* vaccination within 14 days before first test article administration, or have plans to receive vaccination during the study period
* history of cardiovascular diseases
* history of mental conditions including depression, aggressive behaviours, epilepsy, etc.
* history of major surgery within 6 months before screen, or have unhealed surgical wounds.
* any clinically significant conditions that investigator believes could affect study outcomes
* history of allergic reactions, or allergic to any components to the study drugs, or have food allergy/special requirement for food that forbids the subject to follow food requirements for the study
* daily cigarette consumption of more than 5 within 3 months before screening, or cannot avoid using cigarette/tabacco products during the study
* history of alcohol abuse (more than 14 units of alcohol per week) within 3 months before screening, or alcohol breath test of \> 0.0 mg/dl at screening
* history of substance abuse, or positive drug results at screening
* history of certain food intake 2 weeks before screening, and/or use of more than 8 cups of tea/coffee/grapefruit juice
* positive pregnancy test results, or pregnant/breast-feeding females
* history of unprotected sexual activities within 1 month before screening
* have plans for child bearing during study period and for 6 months after study, or disagree to take contraceptive measures during study period and for 6 months after study
* history of blood donation or blood loss within 3 months before screening, or have plans to donate blood within 1 month after the study
* any reasons that is deemed unsuitable for study participation as determined by investigator