Clinical trial · Observational
Using Infrared Spectroscopy to Analyze Volatile Organic Compounds (VOCs) in the Breath of Patients With Lung Cancer
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Why stopped (as posted): Change in sponsor's business strategy (disease focus changed to breast cancer)
Summary
Brief summary (as posted)
The goal of this clinical trial is to compare breath samples from patients with lung cancer, those with stable lung nodules, and individuals without lung cancer. The main questions it aims to answer are whether breath patterns are different in these groups and to see if breath patterns change after treatment in patients with lung cancer. Participants will be asked to provide one breath sample, and two if they get treated. They will also be asked to fill out a questionnaire about their background and medical history.
Conditions
Conditions (2)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Lung Cancer | Malignant Lung Neoplasm | CURATED_EXACT | 0.92 |
| Non Small Cell Lung Cancer | Lung Non-Small Cell Carcinoma | ALIAS | 0.90 |
Interventions
Interventions (0)
Data not yet available
Design
Arms and outcomes
Arms (3)
- label
- Confirmed Lung Cancer
- description
- To be eligible for the lung cancer group: * Aged 50 and over; * Current or former smoker with smoking history ≥ 20 pack-years; * Capacity to give informed consent; * Non-metastatic non-small cell lung cancer, that has not been treated * No history of active cancer in the past 5 years (exceptions include: Ductal carcinoma in situ (DCIS), cervical intraepithelial neoplasia (CIN), non-invasive bladder cancer, non-melanoma skin cancers, Gleason prostate cancer ≤ 6); * Able to provide a breath sample. To be eligible for a second breath sample: * Same as above, in addition to, and with the exception of criterion 4: * Non-metastatic non-small cell lung cancer, which has undergone surgical resection; * 6 months since completion of surgery, radiation, and chemotherapy on primary NSCLC; * CT scan at least 6 months after surgical resection, confirming the absence of lung cancer.
- label
- Control
- description
- For a participant to be eligible in the study control group: * Aged 50 and over; * Current or former smoker with smoking history ≥ 20 pack-years; * Capacity to give informed consent; * No history of active lung cancer; * No pulmonary nodule(s); * No active cancer in the last 5 years; (Note: DCIS, CIN, non-invasive bladder cancer, non-melanoma skin cancers, Gleason ≤ 6 prostate cancer will be exceptions); * Ability to provide a breath sample.
- label
- Stable pulmonary nodule
- description
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 50 Years
- Maximum age
- 80 Years
Show eligibility criteria text
Inclusion Criteria: Study participants in the lung cancer and control cohorts must meet lung cancer screening criteria as defined by the PLCOm2012 and/or US Preventative Services Task Force (USPSTF) risk criteria. Exclusion Criteria: * Patients are not eligible if they are currently receiving treatment for lung cancer. * Patients are not eligible for a second breath sample if it has been less than 6 months since last application of treatment. Note: Breath sampling technology is sensitive to chemicals produced by tobacco, cannabis and e-cigarettes as well as alcohol (consumed by the subject or used by the operator around the equipment). We ask participants to refrain from: * Smoking (tobacco, cannabis or e-cigarettes) at least 4 hours before breath sampling; * Consume alcohol (including mouthwash) at least 8 hours before breath sampling.
References
Publications (0)
Data not yet available