French Assessment of MRD by Liquid Biopsies in Stage III CRC Patients (FRENCH.MRD.CRC)

FRENCH.MRD.CRC PART I Inclusion criteria

* Colon or rectal cancer, clinical tumor stage I-III.
* Patient 18 years or older.
* Scheduled for curative intent resection surgery (including "compromised" curative resections).

Exclusion criteria

* Hereditary colorectal cancer linked to familial colonic polyposis or Lynch syndrome.
* Verified distant metastases.
* Malignant colorectal polyps diagnosed after polypectomy.
* Patients who are unlikely to comply with the protocol (e.g. uncooperative attitude), inability to return for subsequent visits) and/or otherwise considered by the Investigator to be unlikely to complete the study.
* Pregnant or nursing woman, or in childbearing age and not willing to use contraception
* Protected and vulnerable adult
* Not covered by Health insurance
* Patient unable to understand and sign written informed consent.

FRENCH.MRD.CRC PART II Inclusion criteria

* Participation in FRENCH.MRD.CRC part 1 - SURGERY
* Colorectal cancer, UICC stage III
* Has received curative-intent resection and is a candidate for adjuvant chemotherapy (3- or 6-months regime) Exclusion criteria
* Inflammatory bowel disease (Crohn's disease or ulcerative colitis) related colon cancer
* Not treated with adjuvant chemotherapy despite indication (incomplete treatment not included)
* Treated with neoadjuvant chemo-radiation therapy
* Synchronous colorectal and non-colorectal cancer diagnosed per operative (except skin cancer other than melanoma)
* Other cancers (excluding colorectal cancer or skin cancer other than melanoma) within 3 years from eligibility screening
* Patients who are unlikely to comply with the protocol (e.g. uncooperative attitude), inability to return for subsequent visits) and/or otherwise considered by the Investigator to be unlikely to complete the study