Clinical trial · Observational
Colorectal Omics and OfCS Proteoglycans
Colorectal OmiCs and Oncofetal Chondroitin Sulfate-modified Proteoglycans
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
This observational study aims to test proteomics, metabolomics and proteoglycans as predictors of postoperative complications after colorectal surgery and as biomarkers of colorectal cancer. The main questions to answer are: * can these biomarkers predict anastomotic leakages * can these biomarkers predict recurrence after colorectal cancer * can these biomarkers be used as diagnostic tests for colorectal cancer * can these biomarkers be identified in the tumor Participants will undergo elective colorectal resection or stoma closure.
Conditions
Conditions (4)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Colorectal Cancer | Malignant Colorectal Neoplasm | CURATED_BROADER | 0.80 |
| Diverticulitis, Colonic | — | UNRESOLVED | — |
| Inflammatory Bowel Diseases | — | UNRESOLVED | — |
| Stoma Colostomy | — | UNRESOLVED | — |
Interventions
Interventions (1)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| Colorectal resection or stoma closure | Procedure | — | UNRESOLVED |
Design
Arms and outcomes
Arms (1)
- label
- Study cohort
- description
- Patients undergoing elective colorectal resection or stoma closure
- interventionNames
- Procedure: Colorectal resection or stoma closure
Primary outcomes (6)
- measure
- Rate of anastomotic leakage diagnosed by CT-scan or reoperation
- timeFrame
- 30 days
- description
- Anastomotic leakage after colorectal resection with anastomosis or stoma closure
- measure
- Rate of major postoperative complications
- timeFrame
- 30 days
- description
- Major postoperative complication (Clavien-Dindo score 3B or higher, and DVT and pulmonary embolism) after colorectal resection with anastomosis or stoma closure
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 18 Years
Show eligibility criteria text
Inclusion Criteria: * Patients diagnosed or with suspicion of colorectal cancer or adenoma, inflammatory bowel disease, late complications to colon diverticulosis, colostomy reversal or other diagnoses requiring colorectal resection. * Patients planned to undergo elective surgical procedures coded as KJFB20-KJFB99, KJFG30-37 or KJGB00-97 according to the Danish modification of the NOMESCO Classification of Surgical Procedures * Able to speak Danish, English, or other languages where professional interpretation is available * Able to give informed consent Exclusion Criteria: * Patients undergoing synchronous: liver resection (patients undergoing metastasectomies can be included); total gastrectomy or cardia resection; Whipple's procedure or another major pancreatic resection (resections of the pancreatic tail can be included); total or partial nephrectomies or cystectomy * Patients previously included in the study * Patients known to be pregnant (pregnancy test not required) * Non-resident in Denmark
References
Publications (0)
Data not yet available