Clinical trial · Interventional
CHARGE Study: CHoice ARchitecture Genetic tEsting
CHARGE: CHOICE ARCHITECTURE IN GENETIC TESTING
NCT06284330CI-TRIAL-00094623CHARGEcompletedN/AClinicalTrials.gov clinicaltrialsProvenance
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
CHARGE is a hybrid type I feasibility study to compare a choice architecture intervention for cascade genetic testing to usual care.
Conditions
Conditions (1)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Hereditary Cancer | Hereditary Malignant Neoplasm | ALIAS | 0.90 |
Interventions
Interventions (1)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| Enhanced cascade testing | Other | — | UNRESOLVED |
Design
Arms and outcomes
Arms (2)
- type
- NO_INTERVENTION
- label
- Standard of care cascade testing
- description
- Standard of care cascade genetic testing
- type
- EXPERIMENTAL
- label
- Choice architecture cascade testing
- description
- Direct mailed genetic testing kit to probands' relatives.
- interventionNames
- Other: Enhanced cascade testing
Primary outcomes (1)
- measure
- Rate of cascade genetic testing
- timeFrame
- 3-6 months
- description
- Proportion of at-risk relatives who undergo testing
Secondary outcomes (4)
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 18 Years
Show eligibility criteria text
Proband Inclusion Criteria: * Have a newly reported pathogenic or likely pathogenic variant in one or more of the following genes: APC, ATM, BRCA1, BRCA2, CDH1, CHEK2, PALB2, MLH1, MSH2, MSH6, PMS2, PTEN, TP53 * 18 years of age or older * English fluency * Have at least 1 adult living genetically related relative who resides in Texas Proband Exclusion Criteria: * Referred for genetic testing by a relative with a pathogenic variant * Unwilling to be randomized to a study arm Relative Inclusion Criteria: * 18 years of age or older * English fluency * Residing in Texas
References
Publications (1)
- DERIVEDMakhnoon S, Getchell G, Rodriguez Y, Pena L, Rodriguez J, Ibidapo T, Henrikson NB, Lee M, Wu S, Pirzadeh-Miller S. Choice architecture in cascade genetic testing (CHARGE study) for hereditary cancer: Design of a hybrid type I randomized feasibility trial. Contemp Clin Trials. 2025 Aug;155:107979. doi: 10.1016/j.cct.2025.107979. Epub 2025 Jun 5. PMID 40482962