Recombinant Human Endostatin Combined With Envafolimab and Synchronal Radiochemotherapy

Inclusion Criteria:

* The patient voluntarily participated in this study, voluntarily underwent treatment and follow-up, and signed an informed consent form;
* According to the International Association for the Study of Lung Cancer and the Joint Committee on Cancer Classification, 8th edition of the TNM staging classification for lung cancer, locally advanced and unresectable stage III non-small cell lung cancer with histopathological diagnosis;
* According to the criteria for evaluating the efficacy of solid tumors (RECIST 1.1), there should be at least one imaging measurable lesion; Patients who have not received PD-1/PD-L1 antibody treatment in the past.
* 18-70 years old; ECOG PS score: 0-1 points; Expected survival period exceeding 3 months;
* Main organ functions meet treatment standards
* Women of childbearing age should agree to use contraceptive measures (such as intrauterine devices, contraceptives, or condoms) during the study period and within 6 months after the end of the study; Within 7 days prior to enrollment in the study, the serum or urine pregnancy test was negative and must be a non lactating patient; Men should agree to patients who must use contraceptive measures during the study period and within 6 months after the end of the study period.

Exclusion Criteria:

* Patients who have previously received PD-1/PD-L1 antibody treatment;
* Respiratory syndrome caused by pleural effusion or ascites (according to NCICTCAE classification ≥ grade 2 dyspnea;
* Patients with brain metastases accompanied by symptoms or symptom control time less than 2 months;
* Has experienced or currently suffers from other malignant tumors within 5 years;
* Within the first 4 weeks of grouping or during the medication period of this study, it is planned to undergo systemic anti-tumor therapy, including cytotoxic therapy and targeted drug therapy. Received radiotherapy within 4 weeks prior to grouping;
* Patients with any severe and/or uncontrolled diseases
* Received significant surgical treatment, open biopsy, or obvious traumatic injury within 28 days prior to grouping;
* Patients with any signs of bleeding or medical history, regardless of severity; Within the first 4 weeks of grouping, patients with any bleeding or bleeding events ≥ CTCAE level 3, with unhealed wounds, ulcers, or fractures;
* Individuals who have experienced arterial/venous thrombosis events within 6 months, such as cerebrovascular accidents (including temporary ischemic attacks), deep vein thrombosis, and pulmonary embolism;
* Individuals with a history of psychiatric drug abuse who are unable to quit or have mental disorders;
* Participated in clinical trials of other anti-tumor drugs within four weeks;
* According to the researcher's judgment, there are accompanying diseases that seriously endanger patient safety or affect patient completion of the study;