Lenvatinib Plus DEB-TACE With/Without FOLFOX-HAIC for Large HCC With PVTT

Inclusion Criteria:

* a confirmed diagnosis of HCC
* the largest intrahepatic lesion \>7 cm
* presence of major PVTT on imaging
* Eastern Cooperative Oncology Group performance status ≤1
* Child-Pugh class A/B
* adequate hematologic and organ function, with leukocyte count 3.0 109/L, neutrophil count 1.5 109/L, platelet count 75 109/L, hemoglobin 85 g/L, alanine transaminase and aspartate transaminase 5 upper limit of the normal, creatinine clearance rate 1.5 upper limit of the normal, and prothrombin time prolongation \<4 s

Exclusion Criteria:

* incomplete medical records
* central nervous system involvement
* previous treatment with transarterial embolization, TACE, HAIC, radiotherapy, or systemic therapy
* history of malignancies other than HCC
* history of organ transplantation
* severe cardiac, pulmonary or renal dysfunction