A Clinical Study of SCTC21C in Participants With CD38+ Hematologic Malignancies

Inclusion Criteria:

1. Male or female aged ≥ 18 years old when signing ICF, weight ≥ 40 kg, ≤ 90 kg
2. Relapsed or refractory CD38+（confirmed by immunohistochemistry or flow cytometry） hematologic malignancies
3. Standard therapies failed or are unavailable or intolerant
4. Participants have at least one of the measurable lesions
5. Eastern Cooperative Oncology Group (ECOG) performance status of 0 to 2
6. Life expectancy ≥3 months
7. Participants with basically normal liver, kidney and heart functions
8. Hematology requirements: platelet≥75x10\^9 /L,absolute neutrophil counts ≥ 1.0x10\^9 /L, hemoglobin ≥ 8.0 g/dL
9. Women of childbearing potential (must have a negative blood pregnancy test within 7 days before the first dose) or male participants must use a highly effective method of contraception from signed ICF to 5 months after the last dose.All participants are prohibited from donating sperms or ova during the study period and 5 months after the last dose

Exclusion Criteria:

1. A history of allergic reactions to any SCTC21C injection or any excipients, or Participants with a history of severe drug allergy
2. Participants who have other antineoplastic drug (except hormones) or radiotherapy within four weeks prior to the first dose of study drug, or the participants who have received immunotherapy or anti-CD38 monoclonal antibody within 6 months
3. Adverse events from the previous treatment have not resolved to ≤ Grade 1
4. Participants with prior immunotherapy and Grade ≥ 3 cytokine release syndrome(CRS)
5. Central nervous system involvement
6. Participants with positive Human immunodeficiency virus (HIV) antibody
7. HBsAg positive with HBV-DNA titer higher than the lower limit of the test value of the research center, or HCV antibody positive with HCV-RNA titer higher than the lower limit of the test value of the research center
8. Active infections that require systemic treatment within 1 week prior to the first dose
9. History of additional malignant tumor or active autoimmune diseases,or participants with other serious medical conditions
10. Participants underwent major surgery within 4 weeks prior to the first dose, or had a surgical schedule during the study period
11. History of allogeneic hematopoietic stem cell transplantation or solid organ transplantation,or history of autologous hematopoietic stem cell transplantation within 6 months prior to screening
12. Participants with significant digestive system dysfunction that may affect drug intake, transport and absorption
13. Participants who have received live vaccines within 30 days prior to the first dose of study drug
14. Participants with mental disorders or poor compliance
15. Female participants who are breastfeeding
16. The Investigator determined that the participant is ineligible for the study for other reasons