Clinical trial · Interventional
Effectiveness of Continous Adjuvant Lidocaine on General Anaesthesia on Tumor Craniotomy Surgery
Effectiveness of Adjuvant Continuous Lidocaine in General Anesthesia on Depth of Anesthesia (qCON), Pain Response (qNOX), and Blood Sugar Levels in Elective Primary Tumor Craniotomy Surgery
NCT06249113CI-TRIAL-00074086completedN/AClinicalTrials.gov clinicaltrialsProvenance
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
This study aims to investigate the effect of adjuvant continuous lidocaine in General Anesthesia on Depth of Anesthesia (qCON), Pain Response (qNOX), and Blood Sugar Levels in Elective Primary Tumor Craniotomy Surgery
Conditions
Conditions (3)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Anesthesia; Functional | — | UNRESOLVED | — |
| Haemodynamic Instability | — | UNRESOLVED | — |
| Surgery | — | UNRESOLVED | — |
Interventions
Interventions (2)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| Adjuvant lidocaine continous | Drug | — | UNRESOLVED |
| NaCl 0.9% | Drug | — | UNRESOLVED |
Design
Arms and outcomes
Arms (2)
- type
- PLACEBO_COMPARATOR
- label
- NaCl 0.9% continous intravenous on tumor craniotomy surgery
- description
- NaCl 0.9% continous intravenous on general anesthesia during tumor craniotomy surgery
- interventionNames
- Drug: NaCl 0.9%
- type
- ACTIVE_COMPARATOR
- label
- Adjuvant lidocaine continous intravenous on tumor craniotomy surgery
- description
- Adjuvant lidocaine continous intravenous on general anesthesia during tumor craniotomy surgery
- interventionNames
- Drug: Adjuvant lidocaine continous
Primary outcomes (3)
- measure
- Depth of Anaesthesia
- timeFrame
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 18 Years
- Maximum age
- 65 Years
Show eligibility criteria text
Inclusion Criteria: * Adult patients aged 18 - 65 years with a diagnosis of brain tumor supratentorial who will undergo craniotomy by opening the dura * ASA physical status 1-3 * Surgery using a head pin * The level of consciousness was assessed with the Glasgow Coma Scale 15 Exclusion Criteria: 1. The patient's family or guardian refuses informed consent included in the research 2. The patient has atrioventricular block 3. There is a midline shift \> 5.4 mm 4. Diagnosis of glioblastoma multiforme or metastases 5. History of allergies to drugs used in the study 6. The patient routinely consumes or is administered class of drugs adrenergic agonists or antagonists (e.g., beta blockers, α-2 agonists, vasodilator, vasoconstrictor or inotropic). 7. The patient has been regularly consuming analgesic agents for the past 2 weeks. 8. The patient has a history of cardiac arrhythmia, kidney or liver disease based on the results of the history and confirmed by further examination. 9. Suffering from diabetes mellitus or taking anti-drugs hyperglycemia based on preoperative assessment.
References
Publications (29)
- BACKGROUNDde Robles P, Fiest KM, Frolkis AD, Pringsheim T, Atta C, St Germaine-Smith C, Day L, Lam D, Jette N. The worldwide incidence and prevalence of primary brain tumors: a systematic review and meta-analysis. Neuro Oncol. 2015 Jun;17(6):776-83. doi: 10.1093/neuonc/nou283. Epub 2014 Oct 13. PMID 25313193
- BACKGROUNDDashti M, Amini S, Azarfarin R, Totonchi Z, Hatami M. Hemodynamic changes following endotracheal intubation with glidescope((R)) video-laryngoscope in patients with untreated hypertension. Res Cardiovasc Med. 2014 May;3(2):e17598. doi: 10.5812/cardiovascmed.17598. Epub 2014 Apr 1. PMID 25478537
- BACKGROUNDCan BO, Bilgin H. Effects of scalp block with bupivacaine versus levobupivacaine on haemodynamic response to head pinning and comparative efficacies in postoperative analgesia: A randomized controlled trial. J Int Med Res. 2017 Apr;45(2):439-450. doi: 10.1177/0300060516665752. Epub 2017 Mar 7. PMID 28415943
- BACKGROUNDGreisen J, Juhl CB, Grofte T, Vilstrup H, Jensen TS, Schmitz O. Acute pain induces insulin resistance in humans. Anesthesiology. 2001 Sep;95(3):578-84. doi: 10.1097/00000542-200109000-00007. PMID 11575527
- BACKGROUNDMarik PE, Bellomo R. Stress hyperglycemia: an essential survival response! Crit Care. 2013 Mar 6;17(2):305. doi: 10.1186/cc12514. PMID 23470218
- BACKGROUNDGruenbaum SE, Meng L, Bilotta F. Recent trends in the anesthetic management of craniotomy for supratentorial tumor resection. Curr Opin Anaesthesiol. 2016 Oct;29(5):552-7. doi: 10.1097/ACO.0000000000000365. PMID 27285727
- BACKGROUNDBeaussier M, Delbos A, Maurice-Szamburski A, Ecoffey C, Mercadal L. Perioperative Use of Intravenous Lidocaine. Drugs. 2018 Aug;78(12):1229-1246. doi: 10.1007/s40265-018-0955-x. PMID 30117019