Clinical trial · Observational
KLHL14 Expression as Predicting Factor of Invasiveness in pitNET
Evaluation of KLHL14 Expression as a Prognostic Factor of PitNET Invasiveness
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
OBJECTIVE: The objective of this study is to evaluate the correlation between KLHL14 expression and its cytoplasm-nuclear localisation and pituitary adenomas biological behaviour with particular focus on its role in epithelial mesenchymal transition and invasion of para and suprasellar regions. This is a multicenter and multidisciplinary study, with the involvement of the Departments of Neurosurgery of the University of Naples Federico II and the Department of Biosciences of the University of Teramo.
Conditions
Conditions (1)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Invasiveness, Neoplasm | — | UNRESOLVED | — |
Interventions
Interventions (1)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| Immunohistochemical expression in pitNET cells of KLHL14 | Other | — | UNRESOLVED |
Design
Arms and outcomes
Arms (1)
- label
- Cases
- description
- All patients undergone surgery for the removal of a pituitary adenoma. Tissue samples of these cases were sent to biochemical essay to measure the expression and localisation of KLHL14.
- interventionNames
- Other: Immunohistochemical expression in pitNET cells of KLHL14
Primary outcomes (1)
- measure
- Invasiveness degree
- timeFrame
- Invasiveness degree will be determined at the time of surgery
- description
- The expression of KLHL14 in invasive pituitary adenomas
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 18 Years
- Maximum age
- 70 Years
Show eligibility criteria text
INCLUSION CRITERIA: * Adult men or women (age 18-70) * Patients affected by nonfunctioning pituitary adenomas. EXCLUSION CRITERIA: * Prisoners * Pregnant women * Patient under 18 years * Patients without capacity of discernment.
References
Publications (0)
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