Clinical trial · Observational
Tranexamic Acid After Pathological Fracture Treated With Modular Arthroplasty
Tranexamic Acid After Pathological Fracture Treated With Modular Arthroplasty: Retrospective Observational Study
NCT06244498CI-TRIAL-00073677completedClinicalTrials.gov clinicaltrialsProvenance
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
This study assesses the safety and efficacy of TXA for patients treated for pathological femur fractures using modular prosthetics.
Conditions
Conditions (1)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Metastases to Bone | — | UNRESOLVED | — |
Interventions
Interventions (1)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| Tranexamic acid injection | Drug | — | UNRESOLVED |
Design
Arms and outcomes
Arms (2)
- label
- TXA
- description
- Tranexamic acid was administered to the participants at a dose of 1.0 g during the induction of anaesthesia and immediately after the operation.
- interventionNames
- Drug: Tranexamic acid injection
- label
- Non-TXA
- description
- Tranexamic acid were not administred to the participants .
Primary outcomes (1)
- measure
- Number of participants who require a blood transfusion.
- timeFrame
- During Hospitalization (up to day 10)
- description
- Need of blood transfusion
Secondary outcomes (2)
- measure
Eligibility
Eligibility (as posted)
- Sex
- All
Show eligibility criteria text
Inclusion Criteria: * Patological fracture * Arthroplasty using a modular prosthesis. Exclusion Criteria: * threatened fracture * intraoperative blood transfusion * fracture fixation
References
Publications (2)
- RESULTCRASH-2 collaborators; Roberts I, Shakur H, Afolabi A, Brohi K, Coats T, Dewan Y, Gando S, Guyatt G, Hunt BJ, Morales C, Perel P, Prieto-Merino D, Woolley T. The importance of early treatment with tranexamic acid in bleeding trauma patients: an exploratory analysis of the CRASH-2 randomised controlled trial. Lancet. 2011 Mar 26;377(9771):1096-101, 1101.e1-2. doi: 10.1016/S0140-6736(11)60278-X. PMID 21439633
- DERIVEDBiega P, Guzik G. Tranexamic Acid Reduces Transfusion Rates After Modular Hemiarthroplasty for Pathological Femoral Fractures: A Retrospective Study. Adv Orthop. 2025 Oct 30;2025:3173784. doi: 10.1155/aort/3173784. eCollection 2025. PMID 41180854