Clinical trial · Observational
Studies of Phenotypic and Functional Characteristics of Circulating Neutrophil Subpopulations in Patients With Lung Cancer
Studies of Phenotypic and Functional Characteristics of Circulating Neutrophil Subpopulations in Patients With Lung Cancer Undergoing Treatment
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
The objective is to study the phenotypic, functional and metabolomic characteristics of neutrophils circulating subpopulations in lung cancer patients, and to compare them to a control group of healthy volunteers. A blood sample will be taken before the first treatment session for the lung cancer patient and a second blood sample will be taken during the first evaluation visit. The investigators hypothesize that there may be different circulating neutrophil subpopulations in patients with metastatic non-small cell lung cancer (NSCLC) involved in tumor progression and resistance to immunotherapy.
Conditions
Conditions (1)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Lung Cancer | Malignant Lung Neoplasm | CURATED_EXACT | 0.92 |
Interventions
Interventions (1)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| Extra blood tubes | Other | — | UNRESOLVED |
Design
Arms and outcomes
Arms (3)
- label
- Lung cancer
- description
- Metastatic, with complete mutational status, without anterior treatment
- interventionNames
- Other: Extra blood tubes
- label
- Chronic obstructive pulmonary disease (COPD)
- description
- Diagnosis of post-smoking COPD (without diagnosis of CP)
- interventionNames
- Other: Extra blood tubes
- label
- Healthy volunteers
- description
- Healthy volunteers (based on biological and clinical data already available from the partner)
- interventionNames
- Other: Extra blood tubes
Primary outcomes (1)
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 18 Years
Show eligibility criteria text
Inclusion Criteria common to lung cancer and COPD patients : * Age ≥ 18 years, * male or female, * affiliated with a Health Insurance, Inclusion Criteria for lung cancer patients : \- Diagnosis of metastatic stage lung cancer with mutation status, naïve treatment Inclusion Criteria for COPD patients : \- Diagnosis of COPD post-smoking Exclusion Criteria: * Tuberculosis or other acute or chronic bacterial infections * Chronic progressive viral infections (Hepatitis B and C, HIV) * Previous or ongoing chemotherapy * Impossibility of giving the subject informed information. * Opposition to the research. * Participation in another research study with an exclusion period still in progress at pre-inclusion (possible inclusion in an observational study) * Vulnerable individual (pregnant, parturient or breastfeeding woman), persons under guardianship or curatorship, or deprived of liberty by a judicial or administrative decision) * Patients benefiting from the AME
References
Publications (0)
Data not yet available