Clinical trial · Observational
Is Desmoplastic Stromal Reaction Useful to Modulate Lymph Node Dissection in Sporadic Medullary Thyroid Carcinoma?
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
The oncologic benefit of lateral neck dissection (LND) during index operation for sporadic medullary thyroid carcinoma (MTC) basing on basal calcitonin (bCT) levels has been questioned due to the potential post-operative complications. This study aims to evaluate desmoplastic reaction (DSR), as predictor of nodal metastases, for definition of surgical strategy. Data from pathological report of MTC after operations between 1997 and 2022 were collected. The primary endpoint of the study was evaluating the risk factors for nodal metastases. The secondary endpoints analyzed the correlations between DSR and nodal metastases and the sensitivity, specificity, positive predictive value (PPV) and negative predictive value (NPV) of DSR for nodal metastases.
Conditions
Conditions (9)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Desmoplasia | — | UNRESOLVED | — |
| Desmoplastic | — | UNRESOLVED | — |
| Desmoplastic Reaction | — | UNRESOLVED | — |
| Lymph Node Disease | — | UNRESOLVED | — |
| Lymph Node Metastasis | — | UNRESOLVED | — |
| Medullary Carcinoma | — | UNRESOLVED | — |
| Medullary Neoplasms | — | UNRESOLVED | — |
| Medullary Thyroid Cancer | Thyroid Gland Medullary Carcinoma | ALIAS | 0.90 |
| Medullary Tumor | — | UNRESOLVED |
Interventions
Interventions (0)
Data not yet available
Design
Arms and outcomes
Arms (0)
[]Primary outcomes (1)
- measure
- Risk factors for nodal metastases
- timeFrame
- January 1997-December 2022
- description
- The primary endpoint of the study consists in the evaluation of risk factors for nodal metastases in patients with histopathologic report of medullary thryoid carcinoma
Secondary outcomes (1)
- measure
- Correlations between desmoplastic stromal reaction and nodal metastases
- timeFrame
- January 1997-December 2022
- description
- The secondary endpoints consist in the evaluation of correlations between desmoplastic stromal reaction and nodal metastases and in the sensitivity, specificity, PPV and PNV of desmoplastic stromal reaction for nodal metastases in patients with histopathologic report of medullary thyroid carcinoma
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 18 Years
Show eligibility criteria text
Inclusion Criteria: * All adults patients who underwent index procedure for sporadic unifocal MTC whose specimens were retrospectively re-evaluated by an expert endocrine pathologist (E.D.R.) for DSR were candidates for inclusion. Exclusion Criteria: * hereditary MTC * sporadic multifocal MTC * index operation in another center * incidental diagnosis of MCT after less than total thyroidectomy and bilateral central neck dissection * less than 6-months-follow-up * patients \< 18 years old
References
Publications (0)
Data not yet available