Clinical trial · Observational
PPIO-006 Primary Tumor Resection for IVa NSCLC
Long-term Outcome of Primary Tumor Resection in Non-Small-Cell Lung Cancer Patients With Dry Pleural Dissemination: A Multi-center Study
NCT06232967CI-TRIAL-00078312completedClinicalTrials.gov clinicaltrialsProvenance
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
The goal of this mutli-center observational study is toinvestigate the impact of primary tumor resection (PTR) on the long-term survival of patients with non-small-cell lung cancer (NSCLC) and dry pleural dissemination (DPD). The main question it aims to answer is: whether primary tumor resection improve long-term survival of NSCLC patients with dry pleural dissemination.
Conditions
Conditions (1)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Non-small-cell Lung Cancer (NSCLC) | Lung Non-Small Cell Carcinoma | ALIAS | 0.85 |
Interventions
Interventions (1)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| Primary tumor resection or not | Procedure | — | UNRESOLVED |
Design
Arms and outcomes
Arms (2)
- label
- Primary tumor resection (PTR group)
- description
- includes wedge resection, segmentectomy, or lobectomy.
- interventionNames
- Procedure: Primary tumor resection or not
- label
- Exploratory thoracotomy (ET group)
- description
- JSimply open and close surgery.
Primary outcomes (1)
- measure
- Disease-specific survival (DSS)
- timeFrame
- Up to 8 years
- description
- The duration from the day of surgery to the the last follow-up visit or to death specifically caused by NSCLC.
Secondary outcomes (1)
- measure
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 18 Years
- Maximum age
- 80 Years
Show eligibility criteria text
Inclusion Criteria: (1) pathologically confirmed primary NSCLC with malignant pleural dissemination, (2) no preoperative treatment, (3) age 80 years or younger, (4) clinicopathologic data and follow-up results were complete. Exclusion Criteria: (1) pleural effusion, contralateral lung metastasis or distant metastasis revealed preoperatively, and (2) with a history of other malignant disease.
References
Publications (1)
- DERIVEDBao T, Deng Y, Chen L, Sun W, Ge M, Zhao X, Chen X, Zhang L, Wang Y, He X, Pu X, He Y, Yu J, Guo W. Primary tumour resection in non-small cell lung cancer patients with pleural dissemination unexpectedly detected during operation: a two-centre retrospective cohort study. BMC Cancer. 2025 Feb 21;25(1):316. doi: 10.1186/s12885-025-13747-3. PMID 39984876