Clinical trial · Observational
Development and Validation of a PSN-AI Prediction Model
Development and Validation of a AI Prognostic Model Based on DNA Ploidy, Stroma, and Nucleotyping for Synchronous Peritoneal Metastasis From Colorectal Cancer
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
Heterogeneity concerning survival in synchronous peritoneal metastasis from patients with colorectal cancer exists, thereby further classification is urgently required. This study aimed to validate a PSN-AI model based on DNA ploidy, stroma-tumor fraction, and nucleotyping (PSN) for the prediction of survival of synchronous peritoneal metastasis from colorectal cancer.
Conditions
Conditions (2)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Colorectal Cancer | Malignant Colorectal Neoplasm | CURATED_BROADER | 0.80 |
| Peritoneal Metastases | Colorectal Neoplasm | PROBABILISTIC | 0.70 |
Interventions
Interventions (1)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| Analyse pathologic slides | Other | — | UNRESOLVED |
Design
Arms and outcomes
Arms (1)
- label
- Validation cohort
- description
- A cohort of consecutive patients from the Sixth Affiliated Hospital of Sun Yat-sen University is used for model validation.
- interventionNames
- Other: Analyse pathologic slides
Primary outcomes (1)
- measure
- Overall survival
- timeFrame
- At least 1-year follow up
- description
- The time between the date of diagnosis and the date of death (due to any cause) or the date of last follow-up.
Secondary outcomes (1)
- measure
- Progression-free survival
- timeFrame
- At least 1-year follow up
- description
- The time from diagnosis to the onset of disease progression.
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 18 Years
- Maximum age
- 80 Years
Show eligibility criteria text
Inclusion Criteria: * Histological proof of synchronous peritoneal metastases of a nonappendiceal colorectal adenocarcinoma. * Resectable disease determined by computed tomography (CT) and a peritoneal cancer index (PCI) of ≤20 at diagnostic laparoscopy or laparotomy; * No evidence of systemic (e.g. liver, lung) colorectal metastases within three months prior to enrolment; * Undergoing cytoreduction surgery for synchronous peritoneal metastasis from colorectal cancer. Exclusion Criteria: * Combined with other types of malignant tumors.
References
Publications (0)
Data not yet available