Clinical trial · Interventional
Adaptive Radiotherapy in Patients With Gynecological Tumors
Prospective Randomized Validation of Adaptive Radiotherapy in Patients With Gynecological Tumors and Indication for Radiotherapy
NCT06230549CI-TRIAL-00073877ProARTrecruitingN/AClinicalTrials.gov clinicaltrialsProvenance
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
Prospective randomized evaluation of adaptive radiotherapy in the definitive radiotherapy of locally advanced gynecologic carcinoma (e.g. cervical carcinoma, endometrial carcinoma, vaginal carcinoma), in the postoperative situation or first series of external beam radiotherapy and in patients in whom radical surgery or HDR brachytherapy as dose boost is not an option.
Conditions
Conditions (8)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Adaptive Radiation Therapy | — | UNRESOLVED | — |
| Adaptive Radiotherapy | — | UNRESOLVED | — |
| Cervical Carcinoma | Cervical Carcinoma | ONTOLOGY_EXACT | 0.98 |
| Curative Treatment | — | UNRESOLVED | — |
| Gynecological Tumor | — | UNRESOLVED | — |
| Image Guided Radiotherapy | — | UNRESOLVED | — |
| Optimization | — | UNRESOLVED | — |
| Radiation | — | UNRESOLVED | — |
Interventions
Interventions (1)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| Adaptive Radiotherapy | Radiation | — | UNRESOLVED |
Design
Arms and outcomes
Arms (2)
- type
- EXPERIMENTAL
- label
- Interventional Arm
- description
- Adaptive Radiotherapy
- interventionNames
- Radiation: Adaptive Radiotherapy
- type
- ACTIVE_COMPARATOR
- label
- Standard conventional Treatment Arm, IGRT
- description
- Standard conventional Treatment Arm, IGRT
- interventionNames
- Radiation: Adaptive Radiotherapy
Primary outcomes (4)
- measure
- Rectal Toxicity
- timeFrame
- 2 weeks to 5 years
- description
Eligibility
Eligibility (as posted)
- Sex
- Female
- Minimum age
- 18 Years
Show eligibility criteria text
Inclusion Criteria: ECOG 0-1 confirmation by histophatology MR of the pelvis staging Exclusion Criteria: Recurrent disease Prior Radiotherapy in pelvic region stage pM1 or cM1
References
Publications (1)
- BACKGROUNDGuberina M, Santiago Garcia A, Khouya A, Pottgen C, Holubyev K, Ringbaek TP, Lachmuth M, Alberti Y, Hoffmann C, Hlouschek J, Gauler T, Lubcke W, Indenkampen F, Stuschke M, Guberina N. Comparison of Online-Onboard Adaptive Intensity-Modulated Radiation Therapy or Volumetric-Modulated Arc Radiotherapy With Image-Guided Radiotherapy for Patients With Gynecologic Tumors in Dependence on Fractionation and the Planning Target Volume Margin. JAMA Netw Open. 2023 Mar 1;6(3):e234066. doi: 10.1001/jamanetworkopen.2023.4066. PMID 36947038