Clinical trial · Observational
Multi-omics Analysis to Characterize the Invasive Evolution of Pulmonary Subsolid Nodules
Cancer Hospital Chinese Academy of Medical Sciences
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
Current clinical follow-up frequency and treatment timing for pulmonary subsolid nodules (SSNs) rely mostly on whether the nodules grow, which may not accurately reflect the pathological status, and may lead to unnecessary follow-ups. This study aims to use multi-omics techniques to dynamically observe the growth and invasiveness evolution process of SSNs and uncover its invasiveness mechanism. Radiological characteristics of SSNs in different invasiveness stages were also analyzed and summarized by analyzing preoperative CT. This can overcome the bottleneck of invasiveness assessment in the growth process of SSN and provide scientific evidence for the scientific management and clinical treatment timing choice of SSN patients, thus facilitating the rational allocation of medical resources and prolonging the expected survival of national health.
Conditions
Conditions (1)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Adenocarcinoma of Lung | Lung Adenocarcinoma | ALIAS | 0.90 |
Interventions
Interventions (1)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| Mass spectrometry-based proteomics | Diagnostic Test | — | UNRESOLVED |
Design
Arms and outcomes
Arms (2)
- label
- Subsolid nodules group
- description
- Patients with pulmonary subsolid nodules were identified by CT examination and intended for surgical treatment. All participants will undergo chest CT, genomic, and proteomic tests to identify related biomarkers and establish a clinical diagnostic model for the invasiveness of subsolid nodules.
- interventionNames
- Diagnostic Test: Mass spectrometry-based proteomics
- label
- Volunteers group
- description
- Healthy volunteers.
- interventionNames
- Diagnostic Test: Mass spectrometry-based proteomics
Primary outcomes (1)
- measure
- Accuracy of subsolid nodule invasive diagnosis
- timeFrame
- Through study completion, an average of 1 year.
- description
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 18 Years
Show eligibility criteria text
Inclusion Criteria: Patients with SSNs 1. Newly diagnosed patients with persistent SSNs confirmed by thin-section chest CT examination 2. Patient areilling to undergo surgery 3. Voluntarily sign a written informed consent form Healthy Volunteers 1. Healthy volunteers aged 18-50 years, regardless of gender. 2. No lung nodules detected on chest thin-section CT. 3. No history of cancer. 4. Voluntary sign a written informed consent form. Exclusion Criteria: Patients with SSNs 1. Surgical contraindications 2. Inability to cooperate with CT/MR examination to obtain high-quality images 3. History of malignant tumors 4. Previous targeted, immune, or ablation therapy 5. Postoperative pathology of non-lung adenocarcinoma disease spectrum 6. Other situations deemed unsuitable for participation in this study by the researchers Healthy Volunteers 1. Drug abuse 2. HIV infection or AIDS 3. History of syphilis, gonorrhea, or other infectious diseases 4. Hepatitis B or C virus carrier
References
Publications (0)
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