Clinical trial · Interventional
PRIORITY-CONNECT 2 Pilot Trial
Virtual Multimodal Hub for Patients Undergoing Major Gastrointestinal Cancer Surgery - PRIORITY-CONNECT 2 Pilot Randomised Type I Hybrid Effectiveness-Implementation Trial
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
The provision of preoperative interventions (prehabilitation: including exercise, nutrition, and psychological treatment) have been reported to reduce postoperative complications by as much as 50% and reduce hospital stay by up to 4 days compared to standard of care. Postoperative multimodal interventions are likely to further benefit patients facing new challenges (e.g. stoma care), and reduce post discharge complications. Therefore the Virtual Multimodal hub of PRIORITY-CONNECT 2 Pilot Trial aims to primarily; determine the feasibility of incorporating a virtual multimodal program into the preoperative and postoperative period for patients undergoing gastrointestinal cancer surgery, the acceptability to patients, clinicians and carers of the virtual multimodal program and the acceptability to patients of being randomised to the virtual multimodal program or usual care. The secondary aim is to obtain pilot data on the likely difference in key outcomes (30 days postoperative complications, quality of life, days at home and alive at 30 days - DAH30, implementation outcomes and cost outcomes) to inform the development of a substantive randomised clinical trial.
Conditions
Conditions (5)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Colorectal Cancer | Malignant Colorectal Neoplasm | CURATED_BROADER | 0.80 |
| Gastric Cancer | Malignant Gastric Neoplasm | CURATED_BROADER | 0.80 |
| Liver Cancer | Malignant Liver Neoplasm | CURATED_EXACT | 0.92 |
| Oesophageal Cancer | — | UNRESOLVED | — |
| Pancreas Cancer | Pancreatic Carcinoma | ALIAS | 0.90 |
Interventions
Interventions (11)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| Postoperative Exercise | Behavioral | — | UNRESOLVED |
| Postoperative Nursing | Other | — | UNRESOLVED |
| Postoperative Nutrition | Dietary Supplement | — | UNRESOLVED |
| Postoperative Peer Support Group | Other | — | UNRESOLVED |
| Postoperative Psychology | Behavioral | — | UNRESOLVED |
| Preoperative Exercise | Behavioral | — | UNRESOLVED |
| Preoperative Nursing | Other | — | UNRESOLVED |
| Preoperative Nutrition | Dietary Supplement | — | UNRESOLVED |
Design
Arms and outcomes
Arms (2)
- type
- EXPERIMENTAL
- label
- Virtual Multimodal Hub and usual care (Intervention Group)
- description
- The main aim of the virtual multimodal hub is to prepare participants for surgery (including the role of Enhanced Recovery after Surgery (ERAS) pathway) and support declines in physiological and psychological function associated with preoperative treatments (e.g., chemo-radiotherapy) and major surgery. The post-hospital discharge interventions will focus on the recovery of activities of daily living, occupational tasks, and recreational activities. Aided by standardised assessment tools, a comprehensive holistic baseline (first preoperative multimodal session) and post-discharge (first postoperative multimodal session) assessment of patients' physical, nutritional, psychological and overall health status, presence of co-morbidities and medical history will determine the frequency, intensity, time, type, volume, and progression of the multimodal interventions.
- interventionNames
- Behavioral: Preoperative Exercise
- Behavioral: Postoperative Exercise
- Dietary Supplement: Preoperative Nutrition
- Dietary Supplement: Postoperative Nutrition
- Behavioral: Preoperative Psychology
- Behavioral: Postoperative Psychology
- Other: Preoperative Nursing
- Other: Postoperative Nursing
- Other: Preoperative Peer Support Group
- Other: Postoperative Peer Support Group
- Other: Usual Care
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 18 Years
Show eligibility criteria text
Inclusion Criteria: * Adults aged ≥18 years undergoing major gastrointestinal elective surgery, including liver, pancreas, oesophagus, gastric and colorectal cancer resections with curative intent * Consulting with a gastrointestinal cancer surgeon at least 1 week prior to scheduled surgery Exclusion Criteria: * Cognitive impairment such that they are unable to provide informed consent * No access to a smart device (including mobile phone, tablet, laptop or desk computer with camera) or no internet connection
References
Publications (1)
- DERIVEDReeves J, Koh C, Smith AB, Mohan H, Carey S, Smith S, Poulton T, Patton V, White K, Laranjo L, Dieng M, Liu X, Denehy L, Wilson K, Allman-Farinelli M, Butow P, Riedel B, Morton RL, Hassett L, Li Q, Delbaere K, Martin O, Dhillon HM, Shailer B, Beardsworth G, Salter M, Cherry K, Rubie F, Reece L, Chan A, Shahab R, Dwyer O, Pring K, Cunningham D, Sheehan K, Iori G, Johnander R, Jeon C, Hirst N, Karunaratne S, Zhou A, Hutchings O, Solomon M, Steffens D; PRIORITY-CONNECT Collaborators. Acceptability and Feasibility of a Virtual Multimodal (P)Rehabilitation Programme for Gastrointestinal Cancer Patients: The PRIORITY-CONNECT 2 Pilot Randomised Controlled Trial. Ann Surg Oncol. 2026 Jun;33(6):5739-5750. doi: 10.1245/s10434-026-19355-0. Epub 2026 Mar 14. PMID 41832362