Clinical trial · Interventional
Evaluation of Infigratinib in Patients With Locally Advanced or Metastatic Gastric Cancer or GEJ Adenocarcinoma
A Phase II, Multicenter, Open-Label, Single Arm Study of Oral Infigratinib Monotherapy in Patients With Locally Advanced or Metastatic Gastric Cancer or Gastroesophageal Junction Adenocarcinoma, Who Harboring FGFR2 Gene Amplification
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Why stopped (as posted): Business Reason
Summary
Brief summary (as posted)
This is a multicenter, open-label, single arm phase II study to evaluate the efficacy and safety of Infigratinib in patients with locally advanced or metastatic GC or GEJ patient with FGFR2 gene amplification, who have failed at least 2 lines of previous standard systemic treatment .
Conditions
Conditions (2)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Gastric Cancer | Malignant Gastric Neoplasm | CURATED_BROADER | 0.80 |
| Gastroesophageal Junction Adenocarcinoma | Gastroesophageal Junction Adenocarcinoma | ONTOLOGY_EXACT | 0.98 |
Interventions
Interventions (1)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| Infigratinib | Drug | Infigratinib | ALIAS |
Design
Arms and outcomes
Arms (1)
- type
- EXPERIMENTAL
- label
- Infigratinib
- description
- Infigratinib 125 mg orally daily, 3 weeks on, 1 week off. . In patients with mild liver function abnormalities or mild renal impairment, the starting dose is 100 mg.
- interventionNames
- Drug: Infigratinib
Primary outcomes (6)
- measure
- Objective response rate (ORR)
- timeFrame
- Week9/17/25/33 and every 12 weeks after (up to 2 years)
- description
- ORR: the proportion of patients with confirmed complete response (CR) or partial response (PR), assessed by the independent review committee (IRC) according to Response Evaluation Criteria in Solid Tumors (RECIST) version (v)1.1.
- measure
- Duration of response (DoR)
- timeFrame
- Week9/17/25/33 and every 12 weeks after (up to 2 years)
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 18 Years
- Maximum age
- 99 Years
Show eligibility criteria text
Inclusion Criteria: * 18 years and older * Histologically or cytologically confirmed locally advanced or metastatic gastric adenocarcinoma, or gastroesophageal junction adenocarcinoma. * Failed at least 2 lines of prior systemic therapy * Willing to undergo tumor biopsy or provide FFPE samples for central lab testing. * At least one measurable tumor lesion by RECIST v1.1 * Eastern cooperative oncology group (ECOG) performance status of 0 or 1. * Life expectancy ≥3 months. * Willing to participate in this study and sign informed consent form, able to read and understand the study, follow the procedures. Exclusion Criteria: * History of other primary malignancies within 3 years except adequately treated in situ carcinoma of the cervix or non-melanoma carcinoma of the skin or any other curatively treated malignancy that is not expected to require treatment for recurrence during the study. * Previous or current treatment of a mitogen-activated protein kinase (MAPK-MEK) or selective FGFR inhibitor. * Any known hypersensitivity to infigratinib or its excipients. * History and/or current evidence of extensive tissue calcification. * Current evidence of endocrine alterations of calcium/phosphate homeostasis. * Have impairment of gastrointestinal (GI) function or GI disease that may significantly alter the absorption of oral infigratinib (such as, ulcerative diseases, uncontrolled nausea, vomiting, diarrhea, malabsorption syndrome, small bowel resection).14. Laboratory abnormality as defined in protocol. * Considered unsuitable to participate in the study by Investigator
References
Publications (0)
Data not yet available