Clinical trial · Interventional
Diaphragm Structure and Function in Childhood Cancer Survivors
Understanding the Influence of Diaphragm Structure and Function on the Control of Breathing During Exercise in Childhood Cancer Survivors (2373GCCC)
NCT06205251CI-TRIAL-00106696completedN/AClinicalTrials.gov clinicaltrialsProvenance
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
The purpose of this research is to study the feasibility of a specific training program for the breathing muscles (inspiratory muscle training) and the effects on how breathing is regulated during exercise in childhood cancer survivors.
Conditions
Conditions (2)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Cancer Survivors | — | UNRESOLVED | — |
| Childhood Cancer | Childhood Malignant Neoplasm | ALIAS | 0.90 |
Interventions
Interventions (1)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| POWERbreathe Plus IMT | Device | — | UNRESOLVED |
Design
Arms and outcomes
Arms (1)
- type
- EXPERIMENTAL
- label
- Inspiratory Muscle Training (IMT)
- description
- Participants will be asked to perform inspiratory muscle training (breathing exercise) 5 days per week for 6 weeks at home.
- interventionNames
- Device: POWERbreathe Plus IMT
Primary outcomes (2)
- measure
- Percent completion
- timeFrame
- 6 weeks
- description
- Percentage of enrolled participants who complete the 6-week inspiratory muscle training protocol
- measure
- Adherence to treatment protocol
- timeFrame
- 6 weeks
- description
- Number of sets and repetitions of training breaths completed during the 6-week inspiratory muscle training protocol
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 6 Years
- Maximum age
- 12 Years
Show eligibility criteria text
Inclusion Criteria: * Completed medical treatment (chemotherapy, chemotherapy/surgery, chemotherapy/radiation or any combination of cancer treatment) for any type of cancer, except for cancer of the central nervous system, at least 1 year ago Exclusion Criteria: * History of neuromuscular, cardiac, or pulmonary disease prior to the diagnosis of cancer * Recent injury or condition (less than 6 months ago) that precludes strength testing or walking * Dyspnea with minimal activity (4 on the modified Medical Research Council Dyspnea Scale)
References
Publications (1)
- DERIVEDHo S, Marchese V. Differential effects of inspiratory muscle training on diaphragm thickness and exercise tolerance in childhood cancer survivors and non-cancer controls. Front Pediatr. 2026 Apr 10;14:1810953. doi: 10.3389/fped.2026.1810953. eCollection 2026. PMID 42038239