Clinical trial · Observational
Atrophic Gastritis Predicts the Risk of Gastric Cancer
Atrophic Gastritis Predicts the Risk of Gastric Cancer: a Prospective Cohort Study
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
Despite declining incidence rates, gastric cancer (GC) ranks the fourth leading cause of cancer-related mortality and the fifth most common cancer worldwide, with the highest incidence reported in Eastern Asia. The 5-year overall survival rate of early GC exceeds 90%, which was well above advanced GC. Most intestinal-type GCs follow the Correa cascade-inflammation,atrophy, intestinal metaplasia (IM), dysplasia and subsequent carcinoma. The presence of gastric mucosal atrophy and intestinal metaplasia are important risk factors for GC. The purpose of this study was to investigate the incidence of GC attributed to atrophic gastritis in a region with high incidence of GC.
Conditions
Conditions (1)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Atrophic Gastritis | — | UNRESOLVED | — |
Interventions
Interventions (3)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| Esophagogastroscopy (OLGA 0-Ⅰ) | Other | — | UNRESOLVED |
| Esophagogastroscopy (OLGA II) | Other | — | UNRESOLVED |
| Esophagogastroscopy (OLGA III-IV) | Other | — | UNRESOLVED |
Design
Arms and outcomes
Arms (3)
- label
- OLGA 0-I
- interventionNames
- Other: Esophagogastroscopy (OLGA 0-Ⅰ)
- label
- OLGA II
- interventionNames
- Other: Esophagogastroscopy (OLGA II)
- label
- OLGA III-IV
- interventionNames
- Other: Esophagogastroscopy (OLGA III-IV)
Primary outcomes (1)
- measure
- early gastric neoplasm
- timeFrame
- After the baseline endoscopy, participants were scheduled for surveillance endoscopies at years 3-5 for subjects with operative link on gastritis assessment (OLGA) 0-Ⅰ, at years 2-3 for subjects with OLGA II and 1 year for subjects with OLGA III-IV.
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 18 Years
- Maximum age
- 70 Years
Show eligibility criteria text
Inclusion Criteria: * Ability and willingness to participate in the study and to sign and give informed consent * Biopsies were collected based on the recommendation of updated Sydney system Exclusion Criteria: * under 18 or over 80 years old * history of gastrectomy * severe systemic diseases or malignancy
References
Publications (0)
Data not yet available