Clinical trial · Interventional
Adapting and Testing a Novel Self-Compassion Intervention to Reduce Lung Cancer Stigma
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
The goal of this pilot clinical trial is to test a disease-tailored, mindfulness-based intervention (Mindful Self-Compassion for Lung Cancer; MSC-LC) in adults diagnosed with lung cancer who are experiencing stigma. The current project seeks to: * Evaluate preliminary evidence for the feasibility, acceptability, and preliminary efficacy of MSC-LC in reducing stigma for adults with lung cancer, compared to a waitlist control condition * Elicit interventional impact not captured through quantitative measures with qualitative data from purposively sampled high responders and non-responders from the intervention condition Participants will randomized to either the MSC-LC intervention (a 10-week, virtually-delivered, group-based psychosocial intervention focused on the development of mindfulness and self-compassion skills) or to a waitlist control group that receives a referral to an NCI list of helpful mental health resources in their community. Researchers will compare the intervention and control groups to see if the MSC-LC intervention reduces lung cancer stigma and increases self-compassion.
Conditions
Conditions (1)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Lung Cancer | Malignant Lung Neoplasm | CURATED_EXACT | 0.92 |
Interventions
Interventions (2)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| Enhanced standard of care with waitlist | Other | — | UNRESOLVED |
| Mindful Self-Compassion for Lung Cancer (MSC-LC) | Behavioral | — | UNRESOLVED |
Design
Arms and outcomes
Arms (2)
- type
- EXPERIMENTAL
- label
- Mindful Self-Compassion for Lung Cancer (MSC-LC)
- description
- Group-based psychosocial intervention adapted from Mindful Self-Compassion that focuses on the development of mindfulness and self-compassion skills to reduce lung cancer stigma.
- interventionNames
- Behavioral: Mindful Self-Compassion for Lung Cancer (MSC-LC)
- type
- ACTIVE_COMPARATOR
- label
- Enhanced standard of care with waitlist
- description
- Control group that will receive a list of mental health resources and will complete questionnaire assessments during a parallel timeframe as participants in the intervention condition and be placed on a waiting list to receive the MSC-LC intervention after study completion.
- interventionNames
- Other: Enhanced standard of care with waitlist
Primary outcomes (1)
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 18 Years
- Maximum age
- 100 Years
Show eligibility criteria text
Inclusion Criteria: * Is at least 18 years of age as per self report; * Has a confirmed lung cancer diagnosis, as per self-report and confirmed by clinician judgment or medical record note; * Endorses elevated levels of lung cancer stigma (scores \>37.5 on the Lung Cancer Stigma Inventory) * Able to read and respond to questions in English Exclusion Criteria: * Inability to understand study procedures or informed consent process, or significant personality dysfunction likely to interfere with study participation, as per study clinician's judgment * Completed a course of Mindful Self-Compassion or an equivalent meditation training in the last year * Use of antidepressant, anxiolytic, antipsychotic, or mood stabilizing medication(s) for which the dose has been initiated or changed within the 8 weeks prior to study entry
References
Publications (2)
- BACKGROUNDWilliamson TJ, Brymwitt WM, Gilliland J, Carter-Bawa L, Mao JJ, Lynch KA, Emard N, Omachi S, Jacobs RL, Tefera MY, Reese MT, Ostroff JS. Mindful self-compassion for lung cancer (MSC-LC): Incorporating perspectives of lung cancer patients, clinicians, and researchers to create an adapted intervention to reduce lung cancer stigma. Transl Behav Med. 2025 Jan 16;15(1):ibae074. doi: 10.1093/tbm/ibae074. PMID 39868945
- BACKGROUNDWilliamson TJ, Brymwitt WM, Ostroff JS, Carter-Bawa L, Germer CK, Hickman SD, Mao JJ, Hamann HA, Riley KE, Studts JL, Reese MT. Mindful self-compassion to reduce stigma among individuals diagnosed with lung cancer (MSC-LC): a pilot study protocol for a parallel-group, randomized controlled trial. Pilot Feasibility Stud. 2026 Mar 20;12(1):57. doi: 10.1186/s40814-026-01808-8. PMID 41862990