Clinical trial · Interventional
Insulin Sensitizers Role in Control of PCOS Vicious Cycle.
Combined Insulin Sensitizers as Double-Weapon to Detonate PCOS-induced Vicious Circle
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
PCOS is a common and complex disease affecting women of reproductive age. It is characterized by its complex pathological symptoms and mechanisms resulting in endocrine and metabolic dysfunction. PCOS is highly associated with various metabolic and endocrinal disorders. Metformin is mainly used for its glucose-lowering effects for treatment and prevention of type-2 diabetes mellitus (DM), gestational DM, and PCOS. Myo-inositol (MI) protects against MAFLD through reduction of hepatic accumulation of triglycerides.
Conditions
Conditions (1)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| PCOS (Polycystic Ovary Syndrome) of Bilateral Ovaries | — | UNRESOLVED | — |
Interventions
Interventions (3)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| Combination of Metformin hydrochloride and MI/DCI | Drug | — | UNRESOLVED |
| Metformin Hydrochloride | Drug | Metformin | ALIAS |
| MI/DCI combination in 40:1 ratio | Drug | — | UNRESOLVED |
Design
Arms and outcomes
Arms (3)
- type
- ACTIVE_COMPARATOR
- label
- Met Group
- interventionNames
- Drug: Metformin Hydrochloride
- type
- ACTIVE_COMPARATOR
- label
- MI Group
- interventionNames
- Drug: MI/DCI combination in 40:1 ratio
- type
- ACTIVE_COMPARATOR
- label
- MM Group
- interventionNames
- Drug: Combination of Metformin hydrochloride and MI/DCI
Primary outcomes (1)
- measure
Eligibility
Eligibility (as posted)
- Sex
- Female
- Minimum age
- 18 Years
- Maximum age
- 45 Years
Show eligibility criteria text
Inclusion Criteria: * Age; * Residence; * level of education \& type of work; * Marital and fertility statuses, and if infertility was the main complaint; * Presence of risk factors as sedentary lifestyle; * Emotional stress and family history of PCOS; * Obesity-related medical disorders especially DM or MAFLD; * History of previous treatment for PCOS and its outcomes; * Menstrual pattern such as infrequent menstrual periods. Exclusion Criteria: * Women had other manifestations of metabolic syndrome: * Cardiac manifestations of PCOS; * Maintained on other therapies or prepared for /received laparoscopic intervention for PCOS; * Receiving scheduled exercise, lipid-lowering therapies, or maintained on diabetogenic drugs for any other indications; * Had morbid obesity with body mass index (BMI) \>35 kg/m2; * Causes other than PCOS for infertility, manifest DM, hepatic or pancreatic diseases.
References
Publications (0)
Data not yet available