Clinical trial · Observational
Retrospective Analysis of the Correlation Between Imaging Features and Pathology, Prognosis in Renal Tumors
Retrospective Analysis of the Correlation Between CT/MRI Imaging Features and Pathology, Prognosis in Patients With Renal Tumors
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
Renal cell carcinoma (RCC) is the most common malignant tumor in the kidney with a high mortality rate. Traditional imaging techniques are limited in capturing the internal heterogeneity of the tumor. Radiomics provides internal features of lesions for precise diagnosis, prognosis prediction, and personalized treatment planning. Early and accurate diagnosis of renal tumors is crucial, but it's challenging due to morphological and pathological overlap between benign and malignant lesions. The accurate diagnosis of RCC, especially for small tumors, remains a significant challenge. Recent studies have shown a relationship between body composition, obesity, and renal tumors. Common indicators like body weight and BMI fail to reflect body composition accurately. Research on the role of body composition, including adipose tissue, in tumor pathology could improve clinical diagnosis and treatment planning.
Conditions
Conditions (4)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Artificial Intelligence | — | UNRESOLVED | — |
| Body Composition | — | UNRESOLVED | — |
| Deep Learning | — | UNRESOLVED | — |
| Radiomics | — | UNRESOLVED | — |
Interventions
Interventions (1)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| radiomics | Diagnostic Test | — | UNRESOLVED |
Design
Arms and outcomes
Arms (2)
- label
- WHO ISUP grading high
- description
- high-grade refer to Grades 3 and 4 tumours with an unfavourable prognosis
- interventionNames
- Diagnostic Test: radiomics
- label
- WHO ISUP grading low
- description
- low-grade refer to Grades 1 and 2 tumours with a promising prognosis
- interventionNames
- Diagnostic Test: radiomics
Primary outcomes (1)
- measure
- WHO/ISUP grade pathologically
- timeFrame
- 1 month
- description
- The WHO ISUP grade of the tumor indicated in the post-operative surgical pathology report
Secondary outcomes (1)
Eligibility
Eligibility (as posted)
- Sex
- All
Show eligibility criteria text
Inclusion Criteria: * Our hospital admits patients with renal tumors in the urology department. The diagnosis is confirmed through surgical pathology, and the patients' imaging data is obtained through contrast-enhanced Computed Tomography or Magnetic Resonance examination in the radiology department. Exclusion Criteria: * Patients who have undergone puncture, microwave, interventional therapies before the examination, or who have received chemotherapy or radiotherapy; * Patients with poor respiratory coordination, resulting in significant image artifacts; * Lesions are cystic, without discernible regions of interest, or with multiple regions of necrosis within the lesion; * Lesions are too small, with a diameter of less than 1cm; * Thin-slice imaging is not available in the CT scan.
References
Publications (1)
- DERIVEDLi S, Zhou Z, Gao M, Liao Z, He K, Qu W, Li J, Kamel IR, Chu Q, Zhang Q, Li Z. Incremental value of automatically segmented perirenal adipose tissue for pathological grading of clear cell renal cell carcinoma: a multicenter cohort study. Int J Surg. 2024 Jul 1;110(7):4221-4230. doi: 10.1097/JS9.0000000000001358. PMID 38573065