Clinical trial · Observational
Effect of Ultrasound Combined With Microbubbles on Blood Perfusion in Invasive Breast Cancer
NCT06158217CI-TRIAL-00071997unknownClinicalTrials.gov clinicaltrialsProvenance
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
Blood perfusion insufficiency and hypoxia are the main causes of drug resistance to chemotherapy in breast cancer. Increasing blood perfusion can improve drug delivery. The cavitation effect of ultrasound-stimulated microbubbles (USMBs) is known to enhance tumor blood perfusion, so we conducted a prospective human study to investigate the effects of USMBs on hemoperfusion in invasive breast cancer (IBC).
Conditions
Conditions (3)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Cavitation | — | UNRESOLVED | — |
| Invasive Breast Cancer | Invasive Breast Carcinoma | ALIAS | 0.90 |
| Perfusion | — | UNRESOLVED | — |
Interventions
Interventions (1)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| ultrasound combined with microbubbles | Procedure | — | UNRESOLVED |
Design
Arms and outcomes
Arms (0)
[]Primary outcomes (3)
- measure
- changes in peak intensity (PI)
- timeFrame
- 15 minutes after the USMB procedure
- description
- PI represents the quantitative scale of the highest average concentration of microbubble (MB) in the region of interest (ROI); thus, a larger PI corresponds to a higher concentration of MB in the ROI.
- measure
- area under the curve (AUC)
- timeFrame
- 15 minutes after the USMB procedure
- description
- AUC represents the total amount of MB passing through the ROI during perfusion; thus, a larger AUC corresponds to greater perfusion in the ROI.
- measure
- percentage increase in the perfusion area (%) of tumor
- timeFrame
- 15 minutes after the USMB procedure
- description
- The percentage increase in the perfusion area (%) was calculated as follows: (perfusion area after the USMB procedure - perfusion area before the USMB procedure) × 100%/perfusion area before the USMB procedure. The greater "percentage increase of perfusion area (%)", the more significant the improvement of blood perfusion.
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 18 Years
Show eligibility criteria text
Inclusion Criteria: * Clinical diagnosis of Invasive Breast Cancer * patients scheduled to undergo surgical resection * maximum lesion diameter \< 4 cm * age over 18 years Exclusion Criteria: * patients with allergies to SonoVue® * patients with severe cardiopulmonary insufficiency, * patients who had already received neoadjuvant chemotherapy * pregnant women * individuals with mental illness * Patients who refused to participate in the study
References
Publications (1)
- DERIVEDDong Y, Zhang D, Feng W, Huang Y, Ge Z, Shi XQ. Effect of Ultrasound Combined with Microbubbles on Blood Perfusion in Invasive Breast Cancer-A Prospective Clinical Trial. Technol Cancer Res Treat. 2026 Jan-Dec;25:15330338261423051. doi: 10.1177/15330338261423051. Epub 2026 Feb 8. PMID 41656585