Clinical trial · Observational
Risk of NSAIDs on Anastomotic Leak for Rectal Surgery
Early Postoperative Non-steroidal Anti-inflammatory Drugs and Anastomotic Leakage for Rectal Cancer
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
Conflicting reports of the association between early postoperative non-steroidal anti-inflammatory drugs (NSAIDs) administration and anastomotic leak (AL) after rectal surgery have continued. The definition of AL and the exposure of NSAIDs differ from each other among studies, which may result in the different conclusions. The aim of this retrospective study was to clarify the effect of NSAIDs on anastomotic leak from new angels.
Conditions
Conditions (2)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Anastomotic Leak | — | UNRESOLVED | — |
| Anti-Inflammatory Agents, Non-Steroidal | — | UNRESOLVED | — |
Interventions
Interventions (1)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| NSAIDs | Drug | — | UNRESOLVED |
Design
Arms and outcomes
Arms (2)
- label
- NSAIDs
- description
- patients were treated with NSAIDs postoperatively
- interventionNames
- Drug: NSAIDs
- label
- No-NSAIDs
- description
- patients were not treated with NSAIDs postoperatively
Primary outcomes (1)
- measure
- The incidence of postoperative anastomotic leak
- timeFrame
- within 30 days
- description
- The primary outcome was anastomotic leak within 30 days after surgery. AL was defined as observing clinical signs of leak (such as high fever, abdominal pain, increasing of inflammatory factors in blood, purulent or fecal drainage from the drain, wound or vagina), and was confirmed by digital imaging or reoperation. Early AL was defined as being confirmed within 6 days postoperatively while late AL was defined as being confirmed after 6 days postoperatively
Secondary outcomes (1)
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 18 Years
Show eligibility criteria text
Inclusion Criteria: * Biopsy-proven adenocarcinoma of the rectum * Age over 18 years old * Patients underwent non-emergency minimally invasive surgery with a primary anastomosis Exclusion Criteria: * Incomplete medical records * Patients with distant metastasis before surgery * Patients with multiple primary colorectal carcinomas
References
Publications (0)
Data not yet available