Acute Myeloid Leukemia Treated With With NETrin Abs in Combination With [AZACITIDINE + VENETOCLAX]

Inclusion Criteria:

I1. Adult is ≥ 65 years of age at the time of signing the ICF (Inform Consent Form)

I2. Histologically confirmed acute myeloid leukemia (AML) as defined by the 2022 World Health Organization (WHO) Classification.

I3. Patient previously untreated for AML (except with the first 2 cycles of his/her current A+V treatment) and who is considered as ineligible for induction regimen and intensive chemotherapy due to age and other comorbidity that the physician judges to be incompatible with such treatment:

OR Patient with expected poor prognosis under intensive /induction chemotherapy (e.g. with complex karyotype) OR "No-go" patients according ALFA decision tool (\[e.i: patient with Adverse cytogenetics ≥1 of the following: mKRAS, mTP53)

Note : Patients with favourable-risk cytogenetics with intensive chemotherapy are not eligible, such as:

* t(8;21)(q22;q22.1); RUNX1-RUNX1T1
* inv(16)(p13.1q22) or t(16;16)(p13.1;q22); CBFB-MYH11
* Mutated NPM1 without FLT3-ITD or with FLT3-ITDlow†
* Biallelic mutated CEBPA

I4. Patients under treatment by A+V treatment as standard first line treatment for AML with no CR nor CRi after 2 cycles of AZACITIDINE +VENETOCLAX.

I5. Patient must be, in the judgment of the investigator, an appropriate candidate for an experimental therapy i.e. with no available other standard treatment or options except palliative care.

I6. Participant must have a life expectancy of at least 12 weeks.

I7. Participants has with Eastern Cooperative Oncology Group (ECOG) performance status of 0 to 2 are eligible to the safety run-in part whatever their age. Then for the expansion part, patient with ECOG PS (Performance Status) of 0 to 2 for subject ≥ 75 years OR of 0 to 3 for subject ≥ 65 to 74 years of age are eligible.

I8. Demonstrate adequate cardiac function:

* QTc (corrected QT interval) ≤470ms
* Resting systolic BP \<160mmHg
* Resting diastolic BP \<100mmHg
* LVEF (left ventricular ejection fraction) ≥50% as determined by multiple-gated acquisition (MUGA) scan or transthoracic echocardiogram.

I9. Demonstrate adequate organ function as defined in table below, all screening laboratory tests should be performed within 7 days prior Cycle 1 day 1 :

* White Blood Cells Count \< 25 × 109/L or lower; use of leukapheresis or hydroxyurea is permitted to achieve this concentration before Cycle 1 Day 1, at the discretion of the treating physician and according to institutional practice. (see exclusion criteria E6)
* Creatinine clearance Calculated creatinine clearance ≥30 mL/min determined by the CKD-EPI (Chronic Kidney Disease Epidemiology Collaboration) formula OR via urine collection for 24-hour creatinine clearance or serum creatinine ≤ 2 upper limit of normal (ULN)
* Bilirubin Total bilirubin \< 2 × the upper limit of normal (ULN) If total bilirubin ≥ 2 ULN, Direct Bilirubin must be \< 2 x ULN unless considered due to leukemic organ involvement(\< 5 ULN) and with the following Exception: Patients with known Gilbert disease who have serum bilirubin level ≤ 3 ULN may be enrolled.
* SGOT (serum glutamate oxaloacetate transaminase) (AST) and SGPT (serum glutamate pyruvate transaminase) (ALT) ≤ 3 x ULN unless considered due to leukemic organ involvement (\< 5 ULN)

I10. Patient has no evidence of spontaneous tumor lysis syndrome (TLS) before NP137 introduction.

I11. Female subjects must be either:

* Postmenopausal; defined no menses for ≥ 12 months without an alternative medical cause; OR
* Permanently surgically sterile (bilateral oophorectomy, bilateral salpingectomy or hysterectomy)

I12. Non-sterile male subjects must use contraceptive methods with partner(s) prior to beginning study drug administration and continuing up to 3.5 months \[106 days\] after the last dose of NP137. Male subjects must agree to refrain from sperm donation from initial study drug administration during this same period.

I13. Patient must understand, sign, and date the written voluntary informed consent form prior to any protocol-specific procedures.

I14. Patient must be able and willing to comply with study visits and procedures as per protocol.

I15. Patients must be covered by a medical insurance

Exclusion Criteria:

E1. Patient who is eligible for any curative therapy including but not limited to induction / intensive chemotherapies, CAR-T cell therapy and agrees to receive this therapy.

E2. Patient previously treated for AML with a hypomethylating agent and/or other chemotherapeutic agents either conventional or experimental for AML before NP137 introduction.

E3. Patient who has acute promyelocytic leukemia.

E4. Patient who experienced:

* Any persisting non hematological grade ≥ 3 AZACITIDINE AND VENETOCLAX related Adverse events before C1D1.
* Any vascular disorder grade ≥ 3 within 6 months prior C1D1.

E5. History of severe allergic anaphylactic reactions (≥ grade 3) to one of the components of the study drugs or to humanized antibodies or premedication and/or any of their excipients.

E6. Prior therapy or needs to be treated with a forbidden concomitant/concurrent therapies/procedures including:

* Any investigational agent or have used an investigational device.
* Major surgery within 4 weeks of start of study treatment. Participants must have recovered adequately from the toxicity and/or complications from the intervention prior to starting study treatment, C1D1.
* Anti-cancer treatment other than those specified in the protocol i.e. AZACITIDINE + VENETOCLAX.
* Live or live-attenuated vaccine within 30 days prior to the first dose of study treatments. Note: Inactivated vaccine are allowed.

Note:

* During the safety run in phase, Hydroxyurea is authorized prior C1D1 but a wash-out period of 2 days or 5\*t1/2 before C1D1 whatever • shorter is required.
* During the expansion phase, the use of hydroxyurea for patients with rapidly proliferative disease is allowed during the course of cycle 1 at the discretion of the treating physician and according to institutional practice

E7. Active or untreated central nervous system involvement.

E8. Other invasive malignancy in the last 2 years except for those with a minimal risk of metastasis or death such as adequately managed in-situ carcinoma of the cervix, basal or squamous cell skin cancer, localized prostate cancer or ductal carcinoma in situ treated with curative intent, previous malignancy confined and surgically resected (or treated with other modalities) with curative intent.

E9. Patients with any other known concurrent severe and/or uncontrolled medical condition including but not limited to diabetes, cardiovascular disease including hypertension, renal disease, or active uncontrolled infection, which could compromise participation in the study. For active infection requiring systemic therapy or fever likely secondary to infection within prior 48 hours: prophylactic antibiotics or prolonged course of IV antibiotics for controlled infection are allowed.

E10. Patients with uncontrolled hypertension despite adequate medical therapy, active and uncontrolled congestive heart failure New York Heart Association (NYHA) class III/IV, clinically significant and uncontrolled arrhythmia as judged by the treating physician.

E11. Patient with evidence of uncontrolled active infection requiring systemic therapy (viral, bacterial or fungal).

E12. Patients known to be positive to HIV (testing will be performed a screening).

E13. Patients known to be positive for hepatitis B or C infection with the exception of those with an undetectable viral load within 3 months. Hepatitis B or C testing is not required and subjects with serologic evidence of prior vaccination to Hepatitis B virus (i.e., HBs Ag, anti-HBs+ and anti-HBc-) may participate.

Patients placed under a legal protection regimen: Judicial Safeguards, curatorship or guardianship.