Clinical trial · Observational
Comparison of Long-term Survival and Quality of Life After Minimally Invasive Esophagectomy Versus Open Esophagectomy
Comparison of Long-term Survival and Quality of Life After Minimally Invasive Esophagectomy Versus Open Esophagectomy for Esophageal Cancer: a Retrospective Cohort Study
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
To analyze and compare the long-term recurrence-free survival rate, overall survival rate and quality of survival after minimally invasive esophagectomy and open esophagectomy, and to conduct subgroup analysis according to the type of esophageal cancer and pathological stage, etc., and to explore more deeply the differences between minimally invasive esophagectomy and open esophagectomy in terms of the benefits for different types of patients, so as to provide reference for the selection of the clinical surgical methods. We will also use the available data to analyze the influence of other factors on patients\' long-term survival after surgery.
Conditions
Conditions (4)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Esophagectomy | — | UNRESOLVED | — |
| Esophagus Cancer | Esophageal Neoplasm | PROBABILISTIC | 0.70 |
| Quality of Life | — | UNRESOLVED | — |
| Survival | — | UNRESOLVED | — |
Interventions
Interventions (0)
Data not yet available
Design
Arms and outcomes
Arms (2)
- label
- Minimally invasive esophageal cancer resection group
- description
- Surgical Procedures: minimally invasive esophagectomy
- label
- Open esophageal cancer resection group
- description
- Surgical Procedures: open esophagectomy
Primary outcomes (2)
- measure
- Survival Information
- timeFrame
- From enrollment to 5 years after surgery
- description
- Dead or alive 5 years after surgery
- measure
- score of Quality of life
- timeFrame
- From enrollment to 5 years after surgery
- description
- Measured with EORTC QLQ-OES18 Quality of Life Questionnaire
Eligibility
Eligibility (as posted)
- Sex
- All
Show eligibility criteria text
Inclusion Criteria: 1. Patients who had undergone esophageal cancer resection at the Department of Thoracic Surgery, Qilu Hospital, Shandong University, between 2013 and 2021, with pathology results confirming esophageal squamous carcinoma, adenocarcinoma, or other malignant tumors. 2. The surgery was successfully completed, the patient was safely discharged from the hospital, the postoperative follow-up was successful, and if the follow-up patient died, his or her death was due to natural causes. Exclusion Criteria: Perioperative patient deaths, pathologic findings other than those listed above, loss of visits, and postoperative unnatural deaths.
References
Publications (8)
- BACKGROUNDLi Z, Liu C, Liu Y, Yao S, Xu B, Dong G. Comparisons between minimally invasive and open esophagectomy for esophageal cancer with cervical anastomosis: a retrospective study. J Cardiothorac Surg. 2020 Jun 8;15(1):128. doi: 10.1186/s13019-020-01182-3. PMID 32513211
- BACKGROUNDZheng Y, Li Y, Liu X, Sun H, Shen S, Ba Y, Wang Z, Liu S, Xing W. Minimally Invasive Versus Open McKeown for Patients with Esophageal Cancer: A Retrospective Study. Ann Surg Oncol. 2021 Oct;28(11):6329-6336. doi: 10.1245/s10434-021-10105-y. Epub 2021 May 13. PMID 33987755
- BACKGROUNDIsing MS, Smith SA, Trivedi JR, Martin RCG, Phillips P, Van Berkel V, Fox MP. Minimally Invasive Esophagectomy Is Associated with Superior Survival Compared to Open Surgery. Am Surg. 2023 May;89(5):1833-1843. doi: 10.1177/00031348221078962. Epub 2022 Mar 23. PMID 35317621
- BACKGROUNDChen HS, Lin CH, Wu SC, Wang BY. Comparing survival between neoadjuvant chemoradiotherapy followed by open or thoracoscopic oesophagectomy in patients with oesophageal squamous cell carcinoma. Eur J Cardiothorac Surg. 2022 Jul 11;62(2):ezac114. doi: 10.1093/ejcts/ezac114. PMID 35303068
- BACKGROUNDvan der Sluis PC, van der Horst S, May AM, Schippers C, Brosens LAA, Joore HCA, Kroese CC, Haj Mohammad N, Mook S, Vleggaar FP, Borel Rinkes IHM, Ruurda JP, van Hillegersberg R. Robot-assisted Minimally Invasive Thoracolaparoscopic Esophagectomy Versus Open Transthoracic Esophagectomy for Resectable Esophageal Cancer: A Randomized Controlled Trial. Ann Surg. 2019 Apr;269(4):621-630. doi: 10.1097/SLA.0000000000003031. PMID 30308612
- BACKGROUNDKnitter S, Andreou A, Hofmann T, Chopra S, Denecke C, Thuss-Patience PC, Kroll D, Bahra M, Schmelzle M, Pratschke J, Biebl M. Minimally Invasive Versus Open Ivor-Lewis Esophagectomy for Esophageal Cancer or Cancer of the Gastroesophageal Junction: Comparison of Postoperative Outcomes and Long-term Survival Using Propensity Score Matching Analysis. Anticancer Res. 2021 Jul;41(7):3499-3510. doi: 10.21873/anticanres.15137.